Product image of Kivizidiale (Timolol, Travoprost) supplied by GNH India

Kivizidiale

Active Ingredient:
Timolol, Travoprost
Origin:
EU

Kivizidiale (Timolol, Travoprost)

Timolol/Travoprost, the active ingredient in Kivizidiale, is a beta‑blocker; prostaglandin analog presented as an ophthalmic solution for ocular use. It treats primary open‑angle glaucoma and ocular hypertension in adult patients, helping to lower intra‑ocular pressure and reduce risk of vision loss. The dual action provides complementary mechanisms for consistent pressure control.

GNH India supplies Kivizidiale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch + Lomb Ireland Limited

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Indications & Clinical Uses

Kivizidiale is indicated for conditions that require reduction of intra‑ocular pressure within the glaucoma disease spectrum.

  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers eye pressure to prevent conversion to glaucoma.
  • Secondary open‑angle glaucoma: helps control pressure when caused by other ocular conditions.

How It Works

  • Timolol, a non‑selective beta‑adrenergic antagonist, decreases aqueous humor production by blocking beta receptors in the ciliary body, while travoprost, a prostaglandin F2α analog, increases uveoscleral outflow by remodeling extracellular matrix pathways. The combined effect results in a net reduction of intra‑ocular pressure.

Side Effects

Kivizidiale may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision.
  • Redness of the eye.
  • Dry eye or itching.
  • Foreign body sensation.

Serious or Rare Side Effects

  • Severe allergic reaction (angioedema, swelling).
  • Marked bradycardia or heart block.
  • Bronchospasm or worsening asthma.
  • Persistent eye pain or vision loss.
  • Systemic hypotension.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess cardiovascular status: avoid in patients with severe bradycardia or heart block.
  • Evaluate respiratory history: caution in asthma or COPD.
  • Monitor intra‑ocular pressure: ensure adequate pressure reduction.
  • Avoid concurrent use with other beta‑blocker eye drops: may increase systemic absorption.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Kivizidiale can interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Systemic beta‑blockers: additive bradycardia or hypotension.
  • Non‑selective beta‑blocker eye drops: increased systemic exposure.
  • Monoamine oxidase inhibitors: potential hypertensive crisis (rare).

Moderate Interactions (Monitor Closely)

  • Carbonic anhydrase inhibitors: additive intra‑ocular pressure lowering.
  • Topical corticosteroids: may reduce prostaglandin efficacy.
  • Systemic antihypertensives: monitor blood pressure.

Frequently Asked Questions

Kivizidiale is prescribed to lower intra‑ocular pressure in adults with primary open‑angle glaucoma, ocular hypertension, or secondary open‑angle glaucoma. By reducing eye pressure, it helps prevent optic nerve damage and preserves visual function.

Timolol blocks beta‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. Travoprost mimics prostaglandin F2α, enhancing uveoscleral outflow of fluid from the eye. Together they provide a dual mechanism that more effectively lowers intra‑ocular pressure than either agent alone.

The prescribed dose is determined by the treating ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily, but the exact regimen should follow the clinician’s instructions and may be adjusted based on response.

Safety data for Kivizidiale in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against risks and discuss any concerns with the patient before prescribing.

To request Kivizidiale, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with monotherapy agents such as latanoprost or timolol alone, Kivizidiale offers combined pressure‑lowering mechanisms, often achieving greater IOP reduction. This can simplify treatment by reducing the need for multiple separate drops, though individual response varies.

Store Kivizidiale at room temperature, preferably below 25 °C, in the original container. Protect the bottle from direct light and moisture, and keep the cap tightly closed to maintain sterility.

Kivizidiale is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of each prescribed eye. Avoid touching the tip of the bottle to the eye or any surface.

Serious adverse events include severe allergic reactions (e.g., angioedema), marked bradycardia or heart block, bronchospasm in susceptible individuals, and significant systemic hypotension. Patients should seek immediate medical attention if they experience any of these symptoms.

Kivizidiale is contraindicated in patients with known hypersensitivity to timolol, travoprost, or any excipients, as well as those with severe asthma, chronic obstructive pulmonary disease, or advanced heart block. Caution is also advised for individuals with uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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