Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an intravenous solution for intravenous use. It treats a range of bacterial infections, including pneumonia, sinusitis, skin infections, streptococcal pharyngitis, and is part of Helicobacter pylori eradication regimens. GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Klacid is a macrolide antibiotic indicated for several bacterial infections.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating pathogenic organisms.
  • Skin and soft tissue infections: treats cellulitis and wound infections caused by susceptible bacteria.
  • Streptococcal pharyngitis: clears streptococcal infection and relieves throat symptoms.
  • Helicobacter pylori eradication: used in combination therapy to eliminate H. pylori and aid ulcer healing.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This action blocks the elongation of the peptide chain, halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools that may be watery.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Altered taste: metallic or bitter sensation.
  • Headache: mild to moderate pain.
  • Elevated liver enzymes: mild increase in hepatic transaminases.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Hepatotoxicity: significant liver injury.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.

Precautions & Warnings

Before using Klacid, consider the following precautions.

  • Renal impairment: assess kidney function and adjust therapy if needed.
  • Hepatic impairment: monitor liver function tests during treatment.
  • QT prolongation risk: avoid in patients with known prolonged QT or concurrent QT‑prolonging drugs.
  • Drug interactions: review concomitant medications for potential interactions.
  • Pregnancy Category B: use only when the benefit outweighs potential risk.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Clarithromycin interacts with several medicines; monitoring is essential.

Major Interactions (Avoid)

  • Erythromycin or other macrolides: additive QT prolongation.
  • Cisapride: increased risk of serious arrhythmias.
  • Pimozide: heightened QT prolongation potential.
  • Theophylline: elevated plasma concentrations leading to toxicity.
  • Statins (lovastatin, simvastatin): increased risk of myopathy.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR and bleeding risk.
  • Carbamazepine: may reduce clarithromycin levels.
  • Rifampin: may decrease clarithromycin efficacy.
  • Oral contraceptives: potential reduction in contraceptive effectiveness.
  • Antacids containing aluminum or magnesium: may lower clarithromycin absorption.

Frequently Asked Questions

Klacid is indicated for the treatment of community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, streptococcal pharyngitis, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition stops bacterial growth, producing a bacteriostatic effect that helps clear the infection.

The prescribed dose of Klacid is determined by the treating physician based on the type and severity of infection, the patient’s weight, renal and hepatic function, and any relevant drug‑interaction considerations.

Clarithromycin is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy or lactation only when the potential benefit justifies any potential risk to the fetus or infant.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Klacid (clarithromycin) and azithromycin belong to the same macrolide class but differ in pharmacokinetics. Clarithromycin generally requires more frequent dosing and has a broader spectrum against certain Gram‑positive organisms, while azithromycin offers a longer half‑life allowing once‑daily dosing. Choice depends on infection type, susceptibility patterns, and patient factors.

Klacid should be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution to maintain stability.

Klacid is given by intravenous infusion. The solution is typically diluted in compatible IV fluids and infused over a period specified by the prescriber, often 30‑60 minutes, depending on the clinical situation and patient tolerance.

Serious risks include severe allergic reactions such as anaphylaxis, QT interval prolongation leading to cardiac arrhythmias, Clostridioides difficile‑associated colitis, significant liver injury, and rare skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for these events during therapy.

Klacid should be avoided in individuals with known hypersensitivity to clarithromycin or other macrolides, patients with a history of prolonged QT interval, and those taking medications that strongly interact to increase the risk of serious cardiac or hepatic events. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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