Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an intravenous solution for intravenous use. It treats a range of bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, skin and soft‑tissue infections, and is used in Helicobacter pylori eradication regimens.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Sp. Z O.O.

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Indications & Clinical Uses

  • Klacid is a macrolide antibiotic indicated for several bacterial infections.
  • Community‑acquired pneumonia: effective in treating infection caused by susceptible bacteria, improving respiratory symptoms.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears pathogenic organisms.
  • Acute bacterial exacerbations of chronic bronchitis: helps resolve worsening cough and sputum production.
  • Skin and soft‑tissue infections: combats a variety of Gram‑positive and some Gram‑negative skin infections.
  • Helicobacter pylori eradication regimens: used in combination therapy to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This blocks peptide chain elongation, resulting in a bacteriostatic effect at standard concentrations and a bactericidal effect at higher levels, thereby limiting bacterial growth and replication.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools occurring during therapy.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • QT prolongation: cardiac rhythm disturbance that may lead to arrhythmia.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Clostridioides difficile‑associated diarrhea: severe colitis requiring treatment.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Monitor cardiac status: avoid in patients with known QT prolongation or arrhythmias.
  • Use with caution in patients with cardiac disease: increased risk of rhythm disturbances.
  • Avoid in individuals with known macrolide allergy: risk of hypersensitivity reactions.
  • Store at controlled room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Clarithromycin may interact with several medications.

Major Interactions (Avoid)

  • Cisapride and pimozide: risk of severe QT prolongation.
  • Simvastatin and other CYP3A4 substrates: increased plasma concentrations leading to toxicity.
  • Ergot alkaloids: heightened risk of ergotism.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Oral contraceptives: reduced efficacy, consider alternative contraception.
  • Digoxin: increased serum levels, monitor for toxicity.

Frequently Asked Questions

Klacid (clarithromycin) is prescribed for a variety of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination regimens for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis by preventing peptide chain elongation. This action halts bacterial growth (bacteriostatic) and can be bactericidal at higher concentrations, effectively controlling the infection.

The dosage of Klacid is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local guidelines. Only a qualified healthcare professional should set the appropriate dosing regimen.

Clarithromycin is classified as Pregnancy Category B, indicating no evidence of risk in animal studies and insufficient human data. It may be used during pregnancy only if clearly needed. Limited data exist for breastfeeding; the decision should be made by a healthcare provider weighing benefits and risks.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑negative organisms and better tissue penetration compared with older macrolides like erythromycin. It also has a more convenient dosing schedule and fewer drug‑food interactions, making it a preferred choice for many respiratory and skin infections.

Klacid should be stored at controlled room temperature, below 25 °C, in its original packaging. Protect the solution from moisture and direct light to maintain stability and potency throughout its shelf life.

Klacid is supplied as an intravenous solution and is administered by a healthcare professional through a vein, typically using an infusion pump or syringe, following aseptic technique and the dosing instructions provided by the prescriber.

Serious risks include severe allergic reactions (anaphylaxis), QT‑interval prolongation leading to potentially life‑threatening arrhythmias, hepatic dysfunction, and Clostridioides difficile‑associated colitis. Patients should be monitored closely for any signs of these adverse events.

Klacid should be avoided in individuals with a known hypersensitivity to macrolide antibiotics, those with a history of significant QT prolongation or ventricular arrhythmias, and patients taking contraindicated medications that may cause dangerous drug interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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