Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide presented as an oral tablet for oral use. It treats a range of bacterial infections, including respiratory and skin infections, and is used in combination regimens for Helicobacter pylori eradication.
GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Aps

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Indications & Clinical Uses

  • Clarithromycin is a macrolide antibiotic that targets a variety of bacterial infections across several organ systems.
  • Community‑acquired pneumonia: resolves infection and improves pulmonary function.
  • Acute bacterial sinusitis: reduces sinus inflammation and bacterial load.
  • Acute exacerbations of chronic bronchitis: shortens symptom duration and prevents complications.
  • Skin and soft‑tissue infections: eradicates susceptible Gram‑positive and some Gram‑negative pathogens.
  • Helicobacter pylori eradication (in combination therapy): contributes to bacterial clearance when used with a proton‑pump inhibitor and another antimicrobial.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting translocation of the peptidyl‑tRNA. This blocks protein synthesis, leading to a bacteriostatic effect against susceptible organisms. The drug’s affinity for the ribosomal binding site interferes with peptide chain elongation, preventing bacterial growth and replication.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered taste perception.
  • Headache: mild to moderate intensity.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • QT interval prolongation: potential cardiac arrhythmias.
  • Clostridioides difficile infection: severe colitis.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Cardiac arrhythmias: especially in patients with pre‑existing heart disease.
  • Stevens‑Johnson syndrome: rare but serious skin reaction.

Precautions & Warnings

Before prescribing Clarithromycin, clinicians should consider several safety factors.

  • Assess renal function: adjust dosing in impaired kidneys.
  • Monitor liver enzymes: watch for signs of hepatotoxicity.
  • Avoid use in patients with known macrolide allergy: risk of hypersensitivity.
  • Use caution in patients with cardiac arrhythmias: potential QT prolongation.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Cisapride: risk of serious cardiac events.
  • Erythromycin: additive QT prolongation.
  • Theophylline: increased serum concentrations.
  • Warfarin: enhanced anticoagulant effect.
  • Digoxin: elevated plasma levels.

Moderate Interactions (Monitor Closely)

  • Statins (e.g., simvastatin): increased risk of myopathy.
  • Carbamazepine: reduced clarithromycin exposure.
  • Oral contraceptives: possible decreased efficacy.

Frequently Asked Questions

Klacid (clarithromycin) is indicated for several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, skin and soft‑tissue infections, and it is part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition halts bacterial growth, producing a bacteriostatic effect that helps the immune system clear the infection.

The specific dosage of Klacid is determined by the prescribing clinician based on the infection type, severity, patient age, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions precisely.

The safety of clarithromycin in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when appropriate.

To request Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑negative organisms and better tissue penetration compared with older macrolides like erythromycin. It also has a more convenient dosing schedule, but clinicians must consider its interaction profile and potential QT prolongation when selecting therapy.

Klacid should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in areas with high humidity or extreme heat to maintain product stability.

Klacid is administered orally, typically as a tablet taken with or without food as directed by the prescriber. The exact timing and whether it should be taken with meals depend on the specific infection and the clinician’s guidance.

Serious risks include severe allergic reactions, QT interval prolongation leading to cardiac arrhythmias, Clostridioides difficile‑associated colitis, and significant liver enzyme elevations. Patients should be monitored for these events, especially if they have pre‑existing cardiac or hepatic conditions.

Klacid is contraindicated in individuals with a known hypersensitivity to clarithromycin or other macrolide antibiotics. It should also be avoided in patients taking medications that cause dangerous QT prolongation or in those with severe hepatic impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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