Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, and skin infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution, including compliance with EU GMP guidelines and traceability throughout the supply chain.

Manufacturer / TM Owner

Viatris Oy

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat infections of the respiratory and skin pathways.

  • Community‑acquired pneumonia: effective in eradicating the typical bacterial pathogens causing the infection.
  • Acute bacterial sinusitis: reduces symptoms and clears the sinus infection.
  • Acute exacerbations of chronic bronchitis: shortens the duration of bacterial flare‑ups.
  • Skin and soft‑tissue infections: treats cellulitis and other bacterial skin conditions.
  • Helicobacter pylori eradication (in combination therapy): contributes to successful bacterial clearance when used with other agents.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This action blocks the elongation of peptide chains, resulting in a bacteriostatic effect that limits bacterial growth and allows the immune system to eliminate the infection.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: transient upset stomach often occurring after the first dose.
  • Diarrhea: loose stools that may be watery or mild.
  • Abdominal pain: cramping or discomfort in the stomach region.
  • Taste disturbance: altered or metallic taste perception.
  • Headache: mild to moderate headache episodes.
  • Vomiting: occasional emesis, especially with higher doses.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
  • Liver enzyme elevation: potential hepatotoxicity indicated by increased transaminases.
  • QT interval prolongation: risk of cardiac arrhythmias in susceptible individuals.
  • Myocardial arrhythmias: irregular heartbeats that may be life‑threatening.
  • Anaphylaxis: rapid onset of systemic hypersensitivity requiring emergency care.

Precautions & Warnings

Before prescribing Klacid, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor liver enzymes: use with caution in hepatic disease.
  • Avoid in known macrolide hypersensitivity: discontinue if allergic reaction occurs.
  • Review concomitant medications: consider interaction potential.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Clarithromycin can alter the plasma concentrations of several co‑administered drugs, requiring careful management.

Major Interactions (Avoid)

  • Cisapride: may cause life‑threatening arrhythmias.
  • Ergot alkaloids: risk of severe vasospasm and ergotism.
  • Pimozide: can lead to markedly increased plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR; monitor coagulation parameters.
  • Oral contraceptives: may reduce hormonal efficacy; advise additional contraception.

Frequently Asked Questions

Klacid, containing clarithromycin, is prescribed for a range of bacterial infections including community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide chain elongation. This bacteriostatic action halts bacterial growth, allowing the immune system to clear the infection.

The dose of Klacid is individualized by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and any relevant drug‑interaction considerations. No universal dosing regimen is provided here.

Safety data for clarithromycin in pregnancy and lactation are limited. It should be used only when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑positive and atypical organisms compared with older macrolides such as erythromycin. It also has improved acid stability, allowing oral administration, but shares similar interaction and safety profiles characteristic of the macrolide class.

Klacid tablets should be stored at ambient temperature below 25 °C, kept in the original packaging, and protected from moisture and light. Do not store in areas with high humidity or direct sunlight to maintain product stability.

Klacid is taken orally, usually with or without food as directed by the prescriber. The tablet should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, liver enzyme elevation indicating possible hepatotoxicity, QT interval prolongation leading to cardiac arrhythmias, and rare but life‑threatening cardiac events when combined with certain drugs.

Klacid should be avoided in patients with a known hypersensitivity to clarithromycin or other macrolides, in individuals taking contraindicated drugs such as cisapride or ergot alkaloids, and in patients with certain cardiac conditions that predispose them to QT prolongation unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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