Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections, including respiratory, sinus, skin and soft‑tissue infections, and is used in combination regimens for Helicobacter pylori eradication in adults and children as prescribed by a healthcare professional.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

  • Klacid (clarithromycin) is indicated for several bacterial infections affecting the respiratory, sinus, skin and gastrointestinal systems.
  • Community‑acquired pneumonia: eliminates the causative bacteria and improves recovery.
  • Acute bacterial sinusitis: reduces sinus inflammation and bacterial load.
  • Skin and soft‑tissue infections: treats cellulitis, erysipelas and other bacterial skin conditions.
  • Helicobacter pylori eradication (in combination therapy): contributes to successful eradication regimens for ulcer disease.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This blockade prevents peptide chain elongation, halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms. The drug’s affinity for the ribosomal binding site underlies its activity across a broad spectrum of Gram‑positive and some Gram‑negative bacteria.

Side Effects

Clarithromycin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Altered taste: metallic or bitter sensation.
  • Headache: transient mild headache.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Severe allergic reactions: anaphylaxis, rash, or angioedema.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Neutropenia: reduced white blood cell count.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Assess renal and hepatic function: adjust use if impairment is present.
  • Monitor cardiac status: avoid in patients with known QT prolongation.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution during pregnancy: category unknown, weigh benefits against risks.
  • Review concomitant medications: potential for drug‑drug interactions.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness of the interaction level guides management.

Major Interactions (Avoid)

  • Cisapride: risk of serious cardiac arrhythmias.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic levels of clarithromycin.
  • Ergot alkaloids: increased risk of ergotism.
  • Statins metabolized by CYP3A4 (e.g., simvastatin): heightened risk of myopathy.
  • Colchicine in renal impairment: risk of colchicine toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Carbamazepine: may reduce clarithromycin levels.
  • Phenytoin: may lower clarithromycin concentrations.
  • Oral contraceptives: possible reduction in efficacy, advise backup method.
  • Digoxin: may increase serum digoxin levels, monitor for toxicity.

Frequently Asked Questions

Klacid (clarithromycin) is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and it is part of combination therapy for Helicobacter pylori eradication in ulcer disease. The choice of use depends on the prescriber’s assessment of the infection type and susceptibility.

Clarithromycin acts by binding to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition stops the formation of new proteins, halting bacterial growth and leading to a bacteriostatic effect that helps the immune system clear the infection.

The dosage of Klacid is individualized by the prescribing healthcare professional based on the infection being treated, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the exact dosing instructions provided on the prescription label.

Clarithromycin’s pregnancy category is not definitively established, so its use during pregnancy should be considered only when the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult a healthcare provider, as clarithromycin can be excreted in breast milk.

To request Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) shares the macrolide class with azithromycin and erythromycin but has a longer half‑life, allowing twice‑daily dosing, and a broader spectrum against certain Gram‑positive and atypical pathogens. It may have more drug‑interaction potential due to CYP3A4 inhibition compared with azithromycin.

Klacid tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Klacid is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal upset. The exact administration schedule is set by the prescriber.

Serious risks include Clostridioides difficile‑associated diarrhea, QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, hepatic injury, neutropenia, and rare skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience these symptoms.

Klacid should be avoided in individuals with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It is also contraindicated in patients with a history of significant QT prolongation or those taking medications that strongly interact with clarithromycin without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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