Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and is used in combination regimens for Helicobacter pylori eradication.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide from its EU‑origin manufacturing network. All shipments comply with EU quality standards and are supported by comprehensive technical documentation.

Manufacturer / TM Owner

Viatris Italia S.R.L.

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections in various organ systems.

  • Community‑acquired pneumonia: eliminates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears the infection.
  • Skin and soft‑tissue infections: eradicates susceptible Gram‑positive and some Gram‑negative organisms.
  • Helicobacter pylori eradication: part of combination therapy to achieve bacterial eradication and reduce ulcer recurrence.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: mild to moderate.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Severe allergic reactions: anaphylaxis or angioedema.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Clostridioides difficile-associated diarrhea: severe colitis.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Stevens‑Johnson syndrome: severe skin reactions.
  • Cardiac arrhythmias: ventricular tachycardia or fibrillation.

Precautions & Warnings

Before prescribing clarithromycin, clinicians should consider several safety factors.

  • Assess renal function: adjust use in severe impairment.
  • Monitor liver enzymes: watch for hepatotoxicity.
  • Avoid in known macrolide hypersensitivity: risk of severe allergy.
  • Caution in patients with QT prolongation risk: consider ECG monitoring.
  • Use in pregnancy only if benefit outweighs risk: limited data available.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Cisapride and pimozide: risk of serious cardiac arrhythmias.
  • Simvastatin and other CYP3A4 substrates: increased statin levels leading to myopathy.
  • Ergot alkaloids: risk of ergotism.
  • Colchicine: heightened toxicity.
  • Warfarin: enhanced anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy, consider backup method.
  • Carbamazepine and phenytoin: decreased clarithromycin levels.
  • Digoxin: possible increase in serum concentration.
  • Theophylline: altered metabolism, monitor levels.
  • Antacids containing aluminum or magnesium: may affect absorption.

Frequently Asked Questions

Klacid (clarithromycin) is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and it is part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting the translocation step of protein synthesis. This blocks peptide chain elongation, resulting in a bacteriostatic effect that limits bacterial growth.

The dosage of Klacid is determined by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Safety data for clarithromycin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑negative organisms and better tissue penetration compared with older macrolides like erythromycin. It also has a more convenient dosing schedule, though drug‑interaction potential, especially via CYP3A4, is higher than some alternatives.

Klacid should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

Klacid is administered orally, typically as tablets or oral suspension, and should be taken with or without food as directed by the prescriber. The full course should be completed even if symptoms improve early.

Serious risks include severe allergic reactions (anaphylaxis), QT interval prolongation leading to cardiac arrhythmias, Clostridioides difficile‑associated diarrhea, hepatotoxicity, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if these occur.

Klacid is contraindicated in patients with a known hypersensitivity to clarithromycin or other macrolide antibiotics. It should also be avoided in individuals with a history of significant QT prolongation or those taking medications that strongly prolong the QT interval.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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