Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sia

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Indications & Clinical Uses

Klacid is a macrolide antibiotic used to treat infections caused by susceptible bacteria.

  • Community‑acquired pneumonia: effective in resolving bacterial lung infection.
  • Acute bacterial sinusitis: reduces sinus inflammation and bacterial load.
  • Acute otitis media: clears middle‑ear bacterial infection.
  • Skin and soft tissue infections: treats cellulitis and related conditions.
  • Helicobacter pylori eradication: part of combination therapy to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting translocation of the peptidyl‑tRNA. This blocks protein synthesis, leading to bacterial growth inhibition and eventual eradication of susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Abdominal pain: cramping or discomfort.
  • Altered taste: metallic or bitter sensation.
  • Headache: mild to moderate.
  • Rash: skin redness or itching.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Elevated liver enzymes: potential hepatotoxicity.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Hepatic failure: rare but serious liver injury.

Precautions & Warnings

When prescribing or dispensing clarithromycin, consider the following precautions.

  • Assess renal function: adjust use in severe impairment.
  • Monitor liver enzymes: watch for signs of hepatotoxicity.
  • Avoid in known macrolide allergy: contraindicated.
  • Caution with QT‑prolonging drugs: monitor cardiac rhythm.
  • Use with caution in pregnancy: limited safety data available.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase clarithromycin levels.
  • Ciclosporin: risk of nephrotoxicity, avoid co‑administration.
  • Simvastatin: heightened risk of rhabdomyolysis, avoid.
  • Pimozide: can cause serious cardiac arrhythmias, avoid.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR, monitor coagulation.
  • Carbamazepine: may reduce clarithromycin efficacy, monitor therapeutic response.

Frequently Asked Questions

Klacid (clarithromycin) is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute otitis media, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication. The specific use depends on the susceptibility of the infecting organism and the clinician’s judgment.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide elongation. This action stops bacterial growth and leads to the elimination of susceptible microorganisms.

The dosage of Klacid is individualized by the prescribing healthcare professional based on the infection being treated, patient age, weight, renal and hepatic function, and local resistance patterns. Patients should follow the prescriber’s instructions and the product label.

Safety data for clarithromycin in pregnancy are limited, and it should only be used if the potential benefit justifies any potential risk to the fetus. Clarithromycin is excreted in breast milk; breastfeeding mothers should discuss risks and benefits with their healthcare provider.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑positive and atypical organisms compared with older macrolides like erythromycin. It also has a more convenient dosing schedule and better gastric stability, but it shares class‑related drug‑interaction risks, especially with CYP3A4 substrates.

Klacid should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Klacid is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal upset. The exact administration schedule is determined by the prescriber.

Serious risks include Clostridioides difficile‑associated diarrhea, hepatotoxicity indicated by elevated liver enzymes, QT interval prolongation leading to arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like persistent diarrhea, jaundice, palpitations, or rash.

Klacid should not be used by individuals with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It is also contraindicated in patients taking certain medications that have major interactions, such as strong CYP3A4 inhibitors, ciclosporin, simvastatin, or pimozide.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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