Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, and skin and soft‑tissue infections, and is used in adults and children as directed by a healthcare professional.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable supply chain management across diverse markets.

Manufacturer / TM Owner

Viatris Healthcare Sp. Z O.O.

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Indications & Clinical Uses

Clarithromycin is indicated for several bacterial infections affecting the respiratory and skin systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves clinical outcomes.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute exacerbations of chronic bronchitis: shortens symptom duration and prevents complications.
  • Skin and soft‑tissue infections: treats cellulitis, erysipelas, and other bacterial skin conditions.
  • Helicobacter pylori eradication: used in combination therapy to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting translocation of the peptidyl‑tRNA. This blocks protein synthesis, leading to bacterial growth inhibition and eventual cell death, particularly against susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Altered taste: metallic or bitter sensation.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated colitis: severe diarrhea requiring medical attention.
  • Hepatic enzyme elevation: potential liver function abnormalities.
  • Severe hypersensitivity reactions: including anaphylaxis, rash, or Stevens‑Johnson syndrome.

Precautions & Warnings

Before prescribing clarithromycin, clinicians should consider several safety factors.

  • Assess renal function: adjust dose in severe impairment.
  • Monitor liver enzymes: use with caution in hepatic disease.
  • Avoid in known macrolide allergy: discontinue if reaction occurs.
  • Consider QT interval: avoid in patients with prolonged QT or on other QT‑prolonging drugs.
  • Pregnancy and breastfeeding: use only if benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Clarithromycin interacts with several medications; careful management is required.

Major Interactions (Avoid)

  • Statins (simvastatin, lovastatin): increased risk of rhabdomyolysis.
  • Ergot alkaloids: risk of ergotism.
  • Pimozide: heightened risk of arrhythmia.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR and bleeding risk.
  • Theophylline: may raise plasma concentrations.
  • Carbamazepine: may reduce clarithromycin levels, decreasing efficacy.

Frequently Asked Questions

Klacid, containing clarithromycin, is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition stops bacterial growth and leads to the elimination of the infection.

The dosage of Klacid is determined by the prescribing healthcare professional based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Clarithromycin should be used in pregnancy or while breastfeeding only if the potential benefits justify the potential risks to the fetus or infant. Healthcare providers will evaluate the individual situation before prescribing.

To order Klacid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) offers a broader spectrum against certain Gram‑negative organisms compared with older macrolides like erythromycin, and it has a more convenient dosing schedule. However, drug‑interaction potential, especially with CYP3A4 substrates, may differ and should be reviewed by the prescriber.

Klacid should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the container tightly closed and out of direct sunlight.

Klacid is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule depends on the infection being treated and the dosage prescribed.

Serious risks include Clostridioides difficile‑associated colitis, significant liver enzyme elevations, and severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience severe diarrhea, rash, or signs of liver injury.

Klacid should not be used by individuals with a known hypersensitivity to clarithromycin, other macrolides, or any of the tablet’s excipients. It is also contraindicated in patients taking medications that may cause dangerous interactions, such as certain statins, ergot alkaloids, or pimozide, unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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