Product image of Klacid (Clarithromycin) supplied by GNH India

Klacid

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid (Clarithromycin)

Clarithromycin, the active ingredient in Klacid, is a macrolide antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, bronchitis, skin and soft‑tissue infections, and is part of combination therapy for Helicobacter pylori eradication.

GNH India supplies Klacid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable efficient global logistics through consistent product availability.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is used to treat bacterial infections across several organ systems and disease categories.

  • Community‑acquired pneumonia: eradicates susceptible Streptococcus pneumoniae and atypical pathogens, improving respiratory function.
  • Acute bacterial sinusitis: reduces bacterial load in sinus mucosa, relieving congestion and pain.
  • Acute bacterial bronchitis: resolves infection and associated cough in adults.
  • Skin and soft‑tissue infections: treats Staphylococcus aureus and Streptococcus pyogenes skin infections.
  • Helicobacter pylori eradication: used in combination regimens to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents the elongation of peptide chains, thereby halting bacterial growth. The drug exhibits a bacteriostatic effect against most susceptible organisms and a bactericidal effect at higher concentrations, targeting Gram‑positive cocci, atypical respiratory pathogens, and certain anaerobes. It also accumulates in phagocytes, enhancing intracellular activity against pathogens.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Altered taste
  • Headache

Serious or Rare Side Effects

  • Anaphylaxis or severe allergic reactions
  • QT interval prolongation leading to arrhythmias
  • Clostridioides difficile‑associated diarrhea or pseudomembranous colitis
  • Hepatic dysfunction or elevated liver enzymes

Precautions & Warnings

Before prescribing clarithromycin, clinicians should consider several precautionary measures to ensure safe use.

  • Assess renal function: adjust dose in severe impairment.
  • Monitor liver enzymes: use with caution in hepatic disease.
  • Review concomitant QT‑prolonging drugs: avoid additive cardiac risk.
  • Evaluate for known macrolide allergy: contraindicated if hypersensitivity.
  • Use during pregnancy only if benefit outweighs risk: limited safety data.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Cisapride: risk of serious arrhythmia.
  • Pimozide: may cause QT prolongation.
  • Ergot alkaloids: risk of ergotism.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may lower clarithromycin absorption.
  • Warfarin: may increase INR, requiring coagulation monitoring.
  • Statins metabolized by CYP3A4 (e.g., simvastatin, lovastatin): may raise statin levels, monitor for myopathy.

Frequently Asked Questions

Klacid (clarithromycin) is indicated for several bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial bronchitis, skin and soft‑tissue infections, and it is part of combination therapy for Helicobacter pylori eradication.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide chain elongation. This action stops bacterial growth and can be bacteriostatic or bactericidal depending on concentration and organism.

The prescribed dose of Klacid is determined by the treating clinician based on the specific infection, patient age, weight, renal and hepatic function, and local prescribing guidelines. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for clarithromycin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To request Klacid, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klacid (clarithromycin) shares the macrolide class with drugs such as azithromycin. Clarithromycin generally has a broader spectrum against certain atypical pathogens and higher tissue penetration, but it may have more drug‑interaction potential due to CYP3A4 inhibition compared with azithromycin.

Klacid should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat to maintain product stability.

Klacid is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal upset in some patients. Swallow tablets whole; do not crush or chew unless advised by a clinician.

Serious adverse events include severe allergic reactions such as anaphylaxis, QT‑interval prolongation that can lead to cardiac arrhythmias, Clostridioides difficile‑associated colitis, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms like rash, palpitations, or persistent diarrhea.

Klacid is contraindicated in individuals with a known hypersensitivity to clarithromycin or other macrolide antibiotics. It should also be avoided in patients with a history of significant QT prolongation, severe hepatic impairment, or those taking medications that have a high risk of dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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