Product image of Klacid Forte (Clarithromycin) supplied by GNH India

Klacid Forte

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Forte (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Forte, is a macrolide antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, and skin infections in adults and children as prescribed.

GNH India supplies Klacid Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

  • Klacid Forte is a macrolide antibiotic indicated for several bacterial infections affecting the respiratory and skin systems.
  • Community‑acquired pneumonia: eradicates the causative bacteria, improving respiratory function and reducing disease duration.
  • Acute bacterial sinusitis: clears sinus infection, relieving congestion and facial pain.
  • Acute exacerbations of chronic bronchitis: reduces bacterial load, helping to restore normal breathing.
  • Skin and soft tissue infections: eliminates pathogenic bacteria, promoting wound healing.
  • Helicobacter pylori eradication: part of combination therapy to eradicate H. pylori and aid ulcer healing.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This action blocks bacterial growth (bacteriostatic) and, at higher concentrations, can be bactericidal, leading to the elimination of susceptible microorganisms.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: mild to moderate.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Severe allergic reactions: anaphylaxis, rash, swelling.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Clostridioides difficile-associated diarrhea: severe colitis.
  • Stevens‑Johnson syndrome: serious skin reaction.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Known hypersensitivity: avoid in patients with macrolide allergy.
  • Cardiac risk: monitor QT interval in patients with existing heart conditions.
  • Concomitant QT‑prolonging drugs: use with caution to prevent arrhythmias.
  • Pregnancy and lactation: prescribe only if benefits outweigh potential risks.
  • Severe hepatic impairment: consider dose reduction or alternative therapy.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin may interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Erythromycin and other macrolides: additive QT prolongation.
  • Cisapride: increased risk of serious arrhythmias.
  • Pimozide: elevated plasma concentrations leading to toxicity.
  • Terfenadine: risk of cardiac events.
  • Statins metabolized by CYP3A4 (e.g., simvastatin): heightened myopathy risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR and bleeding risk.
  • Theophylline: clarithromycin can raise theophylline levels.
  • Carbamazepine: may reduce clarithromycin efficacy.
  • Oral contraceptives: potential reduction in contraceptive effectiveness.
  • Antacids containing aluminum or magnesium: may decrease clarithromycin absorption.

Frequently Asked Questions

Klacid Forte contains clarithromycin, a macrolide antibiotic used to treat a range of bacterial infections. It is commonly prescribed for community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin works by binding to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition stops bacterial growth (bacteriostatic) and, at higher concentrations, can kill bacteria (bactericidal), thereby eliminating the infection.

The exact dose of Klacid Forte is determined by the prescribing healthcare professional based on the type and severity of the infection, patient age, weight, and renal or hepatic function. Dosage regimens may vary, and patients should follow the prescriber’s instructions precisely.

Clarithromycin’s pregnancy category is not definitively established. It should be used during pregnancy or while breastfeeding only if the potential benefits justify the possible risks to the fetus or infant. Healthcare providers should evaluate each case individually.

To order Klacid Forte, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Klacid Forte (clarithromycin) offers a broader spectrum against certain Gram‑negative organisms compared with azithromycin, and it has a longer half‑life allowing twice‑daily dosing. However, clarithromycin has a higher potential for drug‑drug interactions via CYP3A4 inhibition, whereas azithromycin generally has fewer interactions but may be less effective for some resistant strains.

Klacid Forte tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Klacid Forte is taken orally, usually with a full glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal upset. Tablets should be swallowed whole and not crushed or chewed unless specifically directed by a healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, QT interval prolongation leading to cardiac arrhythmias, hepatic injury, Clostridioides difficile‑associated colitis, and rare skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience symptoms such as rash, chest pain, irregular heartbeat, or persistent diarrhea.

Klacid Forte should not be used by individuals with a known hypersensitivity to clarithromycin, other macrolides, or any of the tablet’s excipients. It is also contraindicated in patients with a history of significant QT prolongation or those taking medications that strongly prolong the QT interval without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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