Product image of Klacid Iv (Clarithromycin) supplied by GNH India

Klacid Iv

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Iv (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Iv, is a macrolide antibiotic presented as an intravenous solution for intravenous use. It treats a range of serious bacterial infections in both adult and pediatric patients when oral therapy is unsuitable.

GNH India supplies Klacid Iv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat infections caused by susceptible bacteria.

  • Community‑acquired bacterial pneumonia: helps eradicate the causative pathogens and improve respiratory function.
  • Skin and soft‑tissue infections: reduces bacterial load in cellulitis, abscesses and wound infections.
  • Intra‑abdominal infections: assists in controlling mixed aerobic and anaerobic bacterial populations.
  • Severe upper respiratory tract infections: alleviates symptoms by targeting the responsible organisms.
  • Septicemia caused by susceptible strains: contributes to systemic infection control.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents the formation of essential bacterial proteins, leading to a bacteriostatic effect that halts bacterial growth and allows the immune system to clear the infection.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: increased bowel movements, sometimes watery.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Altered taste: metallic or bitter sensation.
  • Headache: mild to moderate pain.
  • Rash: skin redness or itching.

Serious or Rare Side Effects

  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile colitis: severe diarrhea with colitis.
  • Stevens‑Johnson syndrome: serious skin and mucous membrane disorder.

Precautions & Warnings

When using Klacid Iv, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust therapy if needed.
  • Hepatic impairment: monitor liver enzymes during treatment.
  • QT prolongation risk: avoid in patients with known prolonged QT or electrolyte disturbances.
  • Drug interactions: review concomitant medications for potential interactions.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Clarithromycin can interact with several medicines; careful management is required.

Major Interactions (Avoid)

  • Cisapride: may cause serious cardiac arrhythmias.
  • Pimozide: increased risk of QT prolongation.
  • Terfenadine: can lead to life‑threatening arrhythmias.
  • Erythromycin and other macrolides: additive QT‑prolongation risk.

Moderate Interactions (Monitor Closely)

  • Statins (simvastatin, lovastatin): heightened risk of myopathy.
  • Warfarin: enhanced anticoagulant effect, monitor INR.
  • Theophylline: increased plasma levels, watch for toxicity.

Frequently Asked Questions

Klacid Iv is an intravenous formulation of clarithromycin, a macrolide antibiotic used to treat serious bacterial infections such as community‑acquired pneumonia, skin and soft‑tissue infections, intra‑abdominal infections, and severe upper respiratory tract infections when oral therapy is not feasible.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the translocation step required for peptide chain elongation. This action stops bacterial growth, allowing the immune system to eliminate the infection.

The dosage of Klacid Iv is determined by the prescribing clinician based on the type and severity of infection, patient age, weight, renal and hepatic function, and local antimicrobial guidelines. The prescriber sets the appropriate regimen.

The safety of clarithromycin in pregnancy and lactation has not been definitively established. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Klacid Iv, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Klacid Iv offers the advantage of intravenous delivery, providing rapid and reliable plasma concentrations, which is useful when oral administration is impossible or when a severe infection requires immediate therapy. Compared with oral macrolides, it bypasses gastrointestinal absorption variability and may achieve higher tissue levels.

Klacid Iv should be stored at 2‑8 °C, protected from light, and must not be frozen. The solution should be kept in its original container until use, and any unused portion should be discarded according to local regulations.

Klacid Iv is administered by intravenous infusion, typically diluted in compatible IV fluids and infused over a specified period as directed by the prescriber. Administration should be performed by qualified healthcare personnel in a clinical setting.

Serious risks include hepatic dysfunction, QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be monitored for signs of these events, especially if they have pre‑existing cardiac or liver conditions.

Klacid Iv is contraindicated in patients with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It should also be avoided in individuals with a history of significant QT prolongation or those taking drugs that strongly prolong the QT interval.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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