Product image of Klacid Iv (Clarithromycin) supplied by GNH India

Klacid Iv

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Iv (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Iv, is a macrolide antibiotic presented as an intravenous solution for intravenous use. It treats a range of bacterial infections, particularly respiratory and skin infections, in adult and pediatric patients as prescribed by a healthcare professional.

GNH India supplies Klacid Iv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections affecting the respiratory tract, sinuses, skin and gastrointestinal system.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves lung function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute bacterial exacerbation of chronic bronchitis: shortens symptom duration and prevents complications.
  • Skin and soft tissue infections: eliminates pathogenic bacteria and promotes healing.
  • Helicobacter pylori eradication: part of combination therapy to eradicate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This action blocks bacterial growth, rendering the drug primarily bacteriostatic against susceptible organisms and bactericidal at higher concentrations.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Altered taste: metallic or bitter sensation.
  • Headache: mild persistent pain.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Elevated liver enzymes: potential hepatotoxicity.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Hepatobiliary dysfunction: jaundice or liver injury.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Assess renal function: adjust therapy in severe renal impairment.
  • Monitor liver enzymes: watch for signs of hepatotoxicity.
  • Review concomitant medications: avoid drugs that prolong QT interval.
  • Avoid use in patients with known macrolide hypersensitivity.
  • Use caution in patients with pre‑existing cardiac arrhythmias.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Cisapride: may cause serious arrhythmias.
  • Pimozide: risk of severe QT prolongation.
  • Erythromycin or other macrolides: additive QT prolongation.

Moderate Interactions (Monitor Closely)

  • Warfarin: increased anticoagulant effect, monitor INR.
  • Simvastatin or lovastatin: elevated statin levels, monitor for myopathy.
  • Theophylline: increased plasma concentrations, watch for toxicity.

Frequently Asked Questions

Klacid Iv, containing clarithromycin, is indicated for the treatment of community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition stops bacterial growth, providing a bacteriostatic effect that can become bactericidal at higher concentrations.

The dosage of Klacid Iv is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal or hepatic function. Healthcare professionals set the appropriate infusion rate and duration.

The safety of clarithromycin in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To order Klacid Iv, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clarithromycin offers a broader spectrum against certain atypical pathogens and has better tissue penetration compared with some older macrolides like erythromycin. It also has a more favorable dosing schedule for intravenous administration, though drug‑interaction potential remains similar across the class.

Klacid Iv should be stored at room temperature, below 25 °C, in its original packaging. Protect the solution from light, moisture and extreme temperature fluctuations to maintain stability.

Klacid Iv is given as an intravenous infusion. The infusion rate and duration are set by the prescriber, typically administered over 30 minutes to 1 hour, depending on the clinical protocol and patient tolerance.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatotoxicity, QT interval prolongation leading to arrhythmias, and rare skin disorders like Stevens‑Johnson syndrome. Prompt medical attention is required if these occur.

Patients with a known hypersensitivity to clarithromycin or other macrolides, those with a history of significant QT prolongation, and individuals taking medications that strongly interact to increase cardiac risk should avoid Klacid Iv unless alternative options are unavailable and benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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