Product image of Klacid Od (Clarithromycin) supplied by GNH India

Klacid Od

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Od (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Od, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections, including community‑acquired pneumonia, acute bacterial sinusitis, and skin and soft‑tissue infections, and is prescribed for adult and pediatric patients when indicated by a healthcare professional.

GNH India supplies Klacid Od as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide through regulated supply chains that meet global quality standards and reliable logistics.

Manufacturer / TM Owner

Viatris As

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections in the respiratory, gastrointestinal and skin categories.

  • Community‑acquired pneumonia: reduces bacterial load and improves clinical outcomes in adults.
  • Acute bacterial sinusitis: eradicates the causative pathogens and relieves sinus inflammation.
  • Acute bacterial exacerbations of chronic bronchitis: shortens the duration of symptoms and prevents further lung damage.
  • Skin and soft‑tissue infections: eliminates susceptible Gram‑positive and some Gram‑negative organisms.
  • Helicobacter pylori eradication regimens: contributes to bacterial clearance when combined with other agents.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: transient gastrointestinal discomfort.
  • Diarrhea: loose stools that may be mild to moderate.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Taste disturbance: altered or metallic taste perception.
  • Headache: mild to moderate intensity.
  • Vomiting: occasional episodes of emesis.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
  • Liver enzyme elevation: potential hepatotoxicity indicated by increased transaminases.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Cardiac arrhythmias: including torsades de pointes in susceptible patients.

Precautions & Warnings

Before prescribing Klacid Od, clinicians should consider several safety aspects.

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Avoid use in patients with known macrolide hypersensitivity: risk of severe allergic reactions.
  • Monitor cardiac rhythm in patients with QT prolongation risk: potential for arrhythmias.
  • Use with caution in pregnancy: limited data, weigh benefits against potential risks.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Clarithromycin can interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Cisapride: may cause serious cardiac arrhythmias.
  • Ergot alkaloids: risk of vasospasm and ischemia.
  • Theophylline: increased plasma concentrations leading to toxicity.
  • Pimozide: heightened risk of QT prolongation.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Simvastatin: increased risk of myopathy, consider dose adjustment.
  • Carbamazepine: may reduce clarithromycin levels, affecting efficacy.

Frequently Asked Questions

Klacid Od contains clarithromycin, a macrolide antibiotic indicated for treating bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of Helicobacter pylori eradication regimens when prescribed by a qualified healthcare professional.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This blocks the translocation step of peptide chain elongation, resulting in a bacteriostatic effect that stops the growth of susceptible microorganisms.

The dosage of Klacid Od is individualized by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions and the product label.

Safety data for clarithromycin during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To order Klacid Od, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both clarithromycin and azithromycin belong to the macrolide class and share a similar mechanism of inhibiting bacterial protein synthesis. Clarithromycin generally has a broader spectrum against certain Gram‑positive organisms and a longer half‑life, while azithromycin offers once‑daily dosing and may have fewer drug‑interaction concerns, making the choice dependent on the infection type and patient factors.

Klacid Od should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Klacid Od is taken orally, usually with a full glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal upset. Patients should swallow the tablets whole and not crush or chew them unless instructed otherwise.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatotoxicity indicated by elevated liver enzymes, QT interval prolongation leading to cardiac arrhythmias, and potentially life‑threatening cardiac events in susceptible individuals.

Klacid Od should be avoided in individuals with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It is also contraindicated in patients taking medications that have a major interaction risk, such as cisapride or ergot alkaloids, unless alternative therapy is selected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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