Product image of Klacid Paediatric Suspension (Clarithromycin) supplied by GNH India

Klacid Paediatric Suspension

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Paediatric Suspension (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Paediatric Suspension, is a macrolide antibiotic presented as an oral suspension for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute otitis media, sinusitis, and skin infections in children, offering a palatable liquid formulation that can be measured accurately for pediatric dosing.

GNH India supplies Klacid Paediatric Suspension as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections of the respiratory, ear, sinus and skin pathways in pediatric patients.

  • Community‑acquired pneumonia: eliminates causative bacteria and improves respiratory function.
  • Acute otitis media: eradicates ear pathogens and reduces inflammation.
  • Acute bacterial sinusitis: clears sinus infection and relieves congestion.
  • Skin and soft‑tissue infections: treats staphylococcal and streptococcal skin infections.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents the elongation of peptide chains, leading to a bacteriostatic effect against susceptible Gram‑positive and some Gram‑negative organisms, and ultimately halting bacterial growth.

Side Effects

Clarithromycin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Diarrhea: loose stools occurring during therapy.
  • Nausea: feeling of stomach upset.
  • Abdominal pain: discomfort in the stomach area.
  • Taste disturbance: altered taste perception.
  • Rash: mild skin redness or itching.
  • Vomiting: expulsion of stomach contents.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Clostridioides difficile‑associated diarrhea: severe colitis risk.
  • Hepatotoxicity: elevated liver enzymes indicating liver stress.
  • QT prolongation: potential cardiac rhythm disturbances.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.
  • Severe neutropenia: marked reduction in white blood cells.

Precautions & Warnings

When prescribing clarithromycin, clinicians should consider several safety aspects.

  • Assess renal function: adjust dosing in severe renal impairment.
  • Monitor liver enzymes: watch for signs of hepatotoxicity.
  • Avoid in patients with known macrolide hypersensitivity: risk of allergic reactions.
  • Evaluate cardiac risk: consider QT interval prolongation in patients with arrhythmias.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Clarithromycin interacts with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Cisapride: may cause serious cardiac arrhythmias.
  • Ergot alkaloids: increased risk of ergot toxicity.
  • Pimozide: heightened risk of QT prolongation.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR and bleeding risk.
  • Carbamazepine: may reduce clarithromycin plasma levels.
  • Statins (simvastatin): increased risk of myopathy.

Frequently Asked Questions

Klacid Paediatric Suspension, containing clarithromycin, is prescribed for bacterial infections in children such as community‑acquired pneumonia, acute otitis media, acute bacterial sinusitis, and certain skin and soft‑tissue infections caused by susceptible organisms.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide chain elongation. This action stops bacterial growth, providing a bacteriostatic effect against a range of Gram‑positive and some Gram‑negative pathogens.

The dosage of Klacid Paediatric Suspension is determined by the prescribing clinician based on the child’s age, weight, infection type, and severity. The prescriber will calculate the appropriate amount and frequency according to approved pediatric dosing guidelines.

The pregnancy category for clarithromycin is listed as unknown, and safety data for use in pregnant or nursing mothers are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or breastfeeding patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Clarithromycin belongs to the macrolide class, offering a broad spectrum against atypical and some resistant bacteria. Compared with beta‑lactams, it provides coverage for organisms like Mycoplasma and Legionella and is often chosen when patients have penicillin allergies or when macrolide activity is specifically required.

The suspension should be stored at ambient temperature, below 25 °C, in its original container. Keep it away from moisture, direct sunlight, and heat sources. Shake well before each use to ensure uniform drug distribution.

Klacid Paediatric Suspension is taken orally. The prescribed dose is measured with a calibrated syringe or dosing cup to ensure accuracy. It can be given with or without food, but taking it with a small amount of food may reduce gastrointestinal upset.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatotoxicity, QT interval prolongation leading to cardiac arrhythmias, and rare skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for any signs of these conditions.

Children with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation should avoid this product. It is also contraindicated in patients with a history of significant QT prolongation or those taking medications that strongly interact with clarithromycin without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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