Product image of Klacid Pro (Clarithromycin) supplied by GNH India

Klacid Pro

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Pro (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Pro, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections, particularly in the respiratory tract, skin, and soft tissues, and is prescribed for adults and children when indicated by a healthcare professional.

GNH India supplies Klacid Pro as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for healthcare providers across multiple regions.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

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Indications & Clinical Uses

Clarithromycin is used to treat bacterial infections affecting the respiratory tract, ears, skin, and certain gastrointestinal conditions.

  • Community-acquired pneumonia: effective against typical and atypical pathogens, helping resolve lung infection.
  • Acute bacterial sinusitis: reduces sinus inflammation and bacterial load, improving nasal drainage.
  • Acute exacerbations of chronic bronchitis: shortens illness duration and improves breathing function.
  • Skin and soft‑tissue infections: targets Staphylococcus and Streptococcus species, promoting wound healing.
  • Helicobacter pylori eradication (in combination therapy): contributes to ulcer healing by eliminating the bacterium.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents the elongation of peptide chains, halting bacterial growth. The drug exhibits a bacteriostatic effect against most susceptible organisms and a bactericidal effect at higher concentrations, particularly against intracellular pathogens.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: upset stomach often occurring shortly after dosing.
  • Diarrhea: loose stools that may be mild to moderate.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Taste disturbance: altered or metallic taste perception.
  • Headache: mild to moderate head pain.
  • Vomiting: expulsion of stomach contents.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • QT interval prolongation: potential heart rhythm disturbances.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Clostridioides difficile colitis: severe intestinal infection.
  • Stevens‑Johnson syndrome: rare but serious skin reaction.
  • Anaphylaxis: life‑threatening hypersensitivity response.

Precautions & Warnings

Before prescribing clarithromycin, clinicians should consider several safety factors.

  • Assess renal and hepatic function: adjust therapy if impairment present.
  • Avoid use in patients with known macrolide hypersensitivity: may trigger allergic reactions.
  • Monitor cardiac status: risk of QT interval prolongation, especially with other QT‑prolonging drugs.
  • Use caution in pregnancy and lactation: benefits must outweigh potential risks.
  • Consider drug interactions: review concomitant medications for CYP3A4 substrates.
  • Store at ambient temperature: keep below 25°C, in original container, protect from moisture and light.

Avoid Interactions

Clarithromycin interacts with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Cisapride: may cause serious cardiac arrhythmias.
  • Pimozide: increased risk of QT prolongation and cardiac events.
  • Statins metabolized by CYP3A4 (e.g., simvastatin, lovastatin): risk of myopathy.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: may increase serum concentrations, necessitating dose adjustment.

Frequently Asked Questions

Klacid Pro contains clarithromycin, which is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This stops the formation of essential proteins, inhibiting bacterial growth and, at higher concentrations, can kill certain organisms.

The dosage of Klacid Pro is determined by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Safety in pregnancy and lactation has not been definitively established. Clarithromycin should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Klacid Pro, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clarithromycin (Klacid Pro) shares the macrolide class with azithromycin and erythromycin but has a longer half‑life than erythromycin and broader activity against atypical respiratory pathogens. Compared with azithromycin, clarithromycin often requires twice‑daily dosing but may achieve higher tissue concentrations in certain infections.

Klacid Pro should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Klacid Pro is taken orally, usually with a full glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal upset. The exact administration schedule is set by the prescriber.

Serious risks include severe allergic reactions such as anaphylaxis, QT interval prolongation leading to cardiac arrhythmias, hepatic dysfunction, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience symptoms like rash, chest pain, palpitations, jaundice, or persistent diarrhea.

Klacid Pro should be avoided in individuals with a known hypersensitivity to macrolide antibiotics, those taking contraindicated medications such as cisapride or pimozide, and patients with significant QT prolongation or uncontrolled cardiac arrhythmias unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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