Product image of Klacid Sr (Clarithromycin) supplied by GNH India

Klacid Sr

Active Ingredient:
Clarithromycin
Origin:
EU

Klacid Sr (Clarithromycin)

Clarithromycin, the active ingredient in Klacid Sr, is a macrolide antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, skin and soft‑tissue infections, and is included in Helicobacter pylori eradication regimens.

GNH India supplies Klacid Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections of the respiratory tract, skin and gastrointestinal system.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves clinical recovery.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute bacterial exacerbations of chronic bronchitis: shortens symptom duration and prevents complications.
  • Skin and soft‑tissue infections: eliminates pathogenic bacteria and promotes wound healing.
  • Helicobacter pylori eradication regimens: contributes to bacterial clearance when combined with other agents.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, resulting in a bacteriostatic effect that limits bacterial growth and allows the host immune system to clear the infection.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: transient upset stomach.
  • Diarrhea: loose stools, often mild.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered sense of taste.
  • Headache: mild to moderate.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Liver enzyme elevation: hepatitis or jaundice.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.

Precautions & Warnings

Before prescribing clarithromycin, clinicians should consider several safety factors.

  • Assess renal function: adjust use in severe impairment.
  • Monitor liver enzymes: caution in hepatic disease.
  • Avoid in known macrolide hypersensitivity: discontinue if reaction occurs.
  • Consider ECG monitoring: risk of QT prolongation.
  • Use during pregnancy only if benefits outweigh risks: consult obstetric guidance.
  • Store at room temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; careful review is required.

Major Interactions (Avoid)

  • Cisapride: may cause life‑threatening arrhythmias.
  • Pimozide: increased risk of QT prolongation.
  • Theophylline: clarithromycin raises serum levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR; monitor coagulation parameters.
  • Carbamazepine: may reduce clarithromycin exposure; assess therapeutic response.

Frequently Asked Questions

Klacid Sr contains clarithromycin, a macrolide antibiotic indicated for treating community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of Helicobacter pylori eradication regimens.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking peptide chain elongation. This bacteriostatic action limits bacterial growth, allowing the immune system to clear the infection.

The specific dose and treatment duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal or hepatic function. No universal dosing regimen is provided here.

Safety data are limited; clarithromycin should be used during pregnancy only when the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before use.

To request Klacid Sr, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative within the macrolide class is azithromycin, which has a longer half‑life and can be dosed once daily. Clarithromycin often provides higher tissue concentrations but may have more drug‑interaction potential, especially with agents affecting the QT interval.

Klacid Sr tablets should be stored at room temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date.

Klacid Sr is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal upset in some patients.

Serious risks include severe allergic reactions (rash, swelling, anaphylaxis), Clostridioides difficile‑associated colitis, significant liver enzyme elevation, QT interval prolongation leading to arrhythmias, and potentially life‑threatening cardiac events when combined with certain drugs.

Patients with a known hypersensitivity to clarithromycin or other macrolides should avoid it. Those with pre‑existing QT prolongation, significant hepatic impairment, or who are taking contraindicated medications such as cisapride or pimozide should not use Klacid Sr without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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