Product image of Klaricid (Clarithromycin) supplied by GNH India

Klaricid

Active Ingredient:
Clarithromycin
Origin:
EU

Klaricid (Clarithromycin)

Clarithromycin, the active ingredient in Klaricid, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections, including respiratory, sinus, skin, and gastrointestinal infections, in adult and pediatric patients as prescribed.
GNH India supplies Klaricid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Products Limited

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Indications & Clinical Uses

Clarithromycin acts on bacterial infections by inhibiting protein synthesis, making it effective for several common conditions.

  • Community‑acquired pneumonia: resolves infection and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears pathogenic bacteria.
  • Skin and soft tissue infections: eradicates causative organisms and promotes healing.
  • Helicobacter pylori eradication: contributes to combination therapy to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents the elongation of peptide chains, halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: mild to moderate intensity.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • QT prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: rash, angioedema, anaphylaxis.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Arrhythmias: ventricular tachycardia or fibrillation.
  • Hearing loss: reversible or permanent auditory impairment.

Precautions & Warnings

When prescribing Klaricid, consider several safety measures to minimize risk.

  • Liver function assessment: evaluate hepatic status before initiation.
  • Cardiac monitoring: observe QT interval in patients with cardiac disease or electrolyte imbalance.
  • Drug interaction review: check for concurrent CYP3A4 inhibitors or QT‑prolonging agents.
  • Renal impairment caution: adjust therapy in severe renal dysfunction.
  • Hypersensitivity avoidance: do not use in patients with known macrolide allergy.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clarithromycin interacts with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may markedly increase clarithromycin plasma levels.
  • QT‑prolonging agents (e.g., quinidine, sotalol): heightened risk of torsades de pointes.
  • Antacids containing aluminum or magnesium: reduce oral absorption of clarithromycin.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect, requiring INR monitoring.
  • Theophylline: increased serum concentrations, risk of toxicity.
  • Statins (e.g., simvastatin, lovastatin): elevated risk of myopathy or rhabdomyolysis.

Frequently Asked Questions

Klaricid contains clarithromycin, a macrolide antibiotic indicated for treating community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication. It is prescribed by a qualified healthcare professional based on the specific infection and patient characteristics.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide chain elongation. This action halts bacterial growth, producing a bacteriostatic effect against susceptible Gram‑positive and certain Gram‑negative organisms.

The dosage of Klaricid is individualized by the prescribing clinician according to the infection being treated, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare provider.

Safety data for clarithromycin in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant. Pregnant or nursing individuals must discuss use with their healthcare professional.

To order Klaricid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Clarithromycin offers a broader spectrum against certain atypical pathogens compared with azithromycin and has a longer half‑life, allowing twice‑daily dosing. However, it has a higher potential for drug‑drug interactions via CYP3A4 inhibition. Choice of macrolide depends on the infection, patient tolerance, and interaction profile.

Klaricid should be stored at ambient temperature, below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date indicated on the packaging.

Klaricid is taken orally, usually with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal upset. The exact administration schedule is determined by the prescribing clinician.

Serious risks include hepatic dysfunction, QT‑interval prolongation leading to potentially life‑threatening arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and rare cases of irreversible hearing loss. Patients should seek immediate medical attention if they experience symptoms like chest pain, palpitations, severe rash, or persistent diarrhea.

Klaricid is contraindicated in individuals with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It should also be avoided in patients with a history of significant QT prolongation or ventricular arrhythmias unless the benefits outweigh the risks and appropriate monitoring is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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