Product image of Klaricid Od (Clarithromycin) supplied by GNH India

Klaricid Od

Active Ingredient:
Clarithromycin
Origin:
EU

Klaricid Od (Clarithromycin)

Clarithromycin, the active ingredient in Klaricid Od, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections, including respiratory, skin and soft‑tissue, and certain gastrointestinal infections, in adult and pediatric patients where indicated.

GNH India supplies Klaricid Od as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. This ensures reliable access to essential antimicrobial therapy across diverse healthcare settings.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Clarithromycin is employed to treat bacterial infections affecting the respiratory tract, skin, and certain gastrointestinal conditions.

  • Community‑acquired bacterial pneumonia: reduces bacterial load and improves clinical outcomes.
  • Acute bacterial sinusitis: alleviates symptoms and eradicates causative pathogens.
  • Skin and soft‑tissue infections: resolves infection caused by susceptible organisms.
  • Helicobacter pylori eradication (in combination therapy): contributes to successful eradication regimens.
  • Acute exacerbations of chronic bronchitis: shortens duration of symptoms and prevents complications.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents elongation of the peptide chain, halting bacterial growth. The drug exhibits a concentration‑dependent bacteriostatic effect against susceptible Gram‑positive and some Gram‑negative organisms, and at higher concentrations may be bactericidal. It also interferes with bacterial adherence and reduces toxin production, enhancing its therapeutic effect.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often reported.
  • Diarrhea: loose stools that may be self‑limiting.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Taste disturbance: altered or metallic taste.
  • Vomiting: occasional emesis.
  • Headache: mild to moderate headache.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Clostridioides difficile‑associated diarrhea: potentially life‑threatening colitis.
  • Liver enzyme elevation: signs of hepatic injury.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.
  • Hepatotoxicity: rare cases of liver failure.

Precautions & Warnings

When prescribing clarithromycin, clinicians should consider several safety precautions to minimize risk.

  • Assess renal function: adjust use in patients with significant impairment.
  • Monitor liver enzymes: watch for hepatotoxicity during therapy.
  • Avoid use in patients with known QT prolongation: risk of cardiac arrhythmias.
  • Use caution in elderly: higher incidence of adverse effects.
  • Review concomitant medications: avoid strong CYP3A4 inhibitors.
  • Store at room temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Erythromycin: additive macrolide effects increase toxicity risk.
  • Ketoconazole: potent CYP3A4 inhibition can raise clarithromycin levels.
  • Ritonavir: strong CYP3A4 inhibitor leading to elevated plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: increased levels can cause toxicity; monitor concentrations.
  • Simvastatin: risk of increased statin exposure and myopathy; consider dose adjustment.

Frequently Asked Questions

Klaricid Od contains clarithromycin, a macrolide antibiotic indicated for the treatment of susceptible bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step of peptide chain elongation. This action halts bacterial growth and, at higher concentrations, can be bactericidal against a range of Gram‑positive and some Gram‑negative organisms.

The prescribed dose of Klaricid Od is determined by the treating healthcare professional based on the type and severity of infection, patient age, weight, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here.

The safety of clarithromycin in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare provider.

To order Klaricid Od, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both clarithromycin and azithromycin belong to the macrolide class, but clarithromycin generally has a broader spectrum against certain Gram‑positive organisms and a higher potential for drug‑drug interactions via CYP3A4 inhibition. Azithromycin often requires shorter courses and may have fewer gastrointestinal side effects, while clarithromycin may be preferred for specific infections such as H. pylori eradication.

Klaricid Od should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in a bathroom or near a heat source, and keep out of reach of children.

Klaricid Od is taken orally, usually with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal upset. The exact administration schedule is set by the prescriber.

Serious risks include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated colitis, hepatotoxicity, QT interval prolongation leading to cardiac arrhythmias, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, persistent diarrhea, jaundice, or palpitations.

Klaricid Od should be avoided in individuals with a known hypersensitivity to clarithromycin or other macrolides, those with pre‑existing QT prolongation or significant cardiac arrhythmias, and patients taking contraindicated medications that strongly inhibit CYP3A4. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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