Product image of Klariger (Clarithromycin) supplied by GNH India

Klariger

Active Ingredient:
Clarithromycin
Origin:
EU

Klariger (Clarithromycin)

Clarithromycin, the active ingredient in Klariger, is a macrolide antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, bronchitis, skin and soft‑tissue infections, and is used in Helicobacter pylori eradication regimens.

GNH India supplies Klariger as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Clarithromycin is employed to treat infections caused by susceptible bacteria across several organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacterial pathogens and improves respiratory function.
  • Acute bacterial sinusitis: reduces infection and alleviates sinus congestion and pain.
  • Acute bacterial bronchitis: clears bacterial involvement and relieves cough.
  • Skin and soft‑tissue infections: treats susceptible Gram‑positive and some Gram‑negative organisms.
  • Helicobacter pylori eradication (in combination therapy): contributes to bacterial eradication as part of triple‑therapy regimens.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, exerting a bacteriostatic effect against susceptible organisms. The drug’s activity is concentration‑dependent and may become bactericidal at higher concentrations for certain pathogens.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Taste disturbance (metallic taste)
  • Headache
  • Vomiting

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, angioedema)
  • QT interval prolongation and cardiac arrhythmias
  • Clostridioides difficile‑associated colitis
  • Hepatic dysfunction (hepatitis, jaundice)
  • Eosinophilic pneumonia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before prescribing Klariger, clinicians should consider several safety measures.

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Avoid use in patients with known macrolide hypersensitivity.
  • Monitor ECG for QT prolongation in individuals with cardiac risk factors.
  • Use caution when co‑administered with CYP3A4 substrates or inhibitors.
  • Consider alternative therapy in pregnant or breastfeeding women unless benefits outweigh risks.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Cisapride: risk of serious cardiac arrhythmias.
  • Ergot alkaloids: may precipitate ergotism.
  • CYP3A4‑metabolized statins (e.g., simvastatin): increased risk of myopathy.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may reduce clarithromycin absorption.
  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Theophylline: may increase serum theophylline concentrations, risking toxicity.

Frequently Asked Questions

Klariger, containing clarithromycin, is indicated for several bacterial infections including community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition halts peptide chain elongation, resulting in a bacteriostatic effect that limits bacterial growth and allows the immune system to clear the infection.

The dosage of Klariger is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and local treatment guidelines. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for clarithromycin in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified prescriber.

To request Klariger, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Clarithromycin generally offers a broader spectrum against certain Gram‑positive organisms and better activity against atypical pathogens compared with azithromycin. It also has a longer half‑life, allowing twice‑daily dosing, whereas azithromycin often permits once‑daily dosing but may have a different side‑effect profile.

Klariger should be stored at room temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are kept out of reach of children.

Klariger is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal upset. The exact schedule (e.g., twice daily) is set by the prescribing clinician.

Serious risks include severe allergic reactions such as anaphylaxis, QT interval prolongation that can lead to cardiac arrhythmias, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience rash, palpitations, dizziness, or persistent diarrhea.

Klariger should be avoided in individuals with known hypersensitivity to clarithromycin or other macrolides, in patients with severe hepatic impairment, and in those taking medications that have contraindicated interactions, such as cisapride or ergot alkaloids. Pregnant or breastfeeding women should use it only if clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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