Product image of Klavobel Bid (Amoxicillin, Clavulanic Acid) supplied by GNH India

Klavobel Bid

Active Ingredient:
Amoxicillin, Clavulanic Acid
Origin:
EU

Klavobel Bid (Amoxicillin, Clavulanic Acid)

Amoxicillin/clavulanic acid, the active ingredient in Klavobel Bid, is a beta-lactam antibiotic presented as a tablet formulation for oral use. It treats a range of bacterial infections in adults and children, including respiratory, urinary and skin infections, by targeting susceptible Gram‑positive and Gram‑negative organisms.

GNH India supplies Klavobel Bid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, sourcing the product from EU‑regulated manufacturers. The company ensures quality compliance and reliable global distribution.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Klavobel Bid is indicated for bacterial infections affecting various organ systems, acting through inhibition of bacterial cell wall synthesis.

  • Sinusitis: reduces bacterial load and alleviates sinus inflammation.
  • Otitis media: clears middle‑ear infection and improves hearing symptoms.
  • Pneumonia: treats community‑acquired lower respiratory infection.
  • Urinary tract infections: eradicates causative uropathogens.
  • Skin and soft tissue infections: resolves cellulitis and wound infections.

How It Works

  • Amoxicillin binds to penicillin‑binding proteins, blocking the final transpeptidation step of peptidoglycan synthesis, which weakens the bacterial cell wall. Clavulanic acid is a β‑lactamase inhibitor that irreversibly binds to β‑lactamase enzymes produced by resistant bacteria, protecting amoxicillin from enzymatic degradation and extending its spectrum of activity.

Side Effects

Adverse reactions to Klavobel Bid vary in frequency and severity.

Common Side Effects

  • Diarrhea: loose stools, often mild.
  • Nausea: feeling of sickness.
  • Vomiting: expulsion of stomach contents.
  • Rash: mild skin redness or itching.
  • Headache: transient cranial discomfort.
  • Taste disturbance: altered taste perception.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with airway compromise.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Clostridioides difficile‑associated diarrhea: colitis due to bacterial overgrowth.
  • Hepatic enzyme elevation: increased liver transaminases.
  • Neutropenia: reduced neutrophil count.
  • Hemolytic anemia: destruction of red blood cells.

Precautions & Warnings

Before prescribing Klavobel Bid, clinicians should consider several safety precautions.

  • Assess allergy: verify no known penicillin or β‑lactam hypersensitivity.
  • Monitor liver function: clavulanic acid may cause hepatic enzyme elevation.
  • Adjust in renal impairment: dose may need reduction in patients with decreased kidney function.
  • Use with caution in pregnancy: limited data; weigh benefits against potential risks.
  • Avoid in patients with known hypersensitivity to β‑lactam antibiotics: contraindicated.
  • Store at room temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Klavobel Bid may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol: increased risk of severe skin rash.
  • Methotrexate: heightened toxicity due to reduced clearance.
  • Warfarin: possible enhancement of anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced hormonal efficacy, consider backup contraception.
  • Probenecid: decreased renal excretion of amoxicillin, increasing plasma levels.
  • Aminoglycosides: potential additive nephrotoxicity, monitor renal function.

Frequently Asked Questions

Klavobel Bid is a prescription oral antibiotic that treats a variety of bacterial infections, including sinusitis, otitis media, community‑acquired pneumonia, urinary tract infections, and skin or soft‑tissue infections caused by susceptible organisms.

Amoxicillin interferes with bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, while clavulanic acid blocks β‑lactamase enzymes that some bacteria produce to inactivate amoxicillin, thereby extending the antibiotic’s spectrum of activity.

The appropriate dose of Klavobel Bid is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal function. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for amoxicillin/clavulanic acid in pregnancy are limited, and the product is classified as pregnancy category unknown. It should only be used when the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult a healthcare professional, as small amounts may be excreted in milk.

To place an order, submit an enquiry on the Klavobel Bid product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klavobel Bid combines amoxicillin with clavulanic acid, offering broader coverage against β‑lactamase‑producing bacteria compared with amoxicillin alone. It is often preferred over plain penicillins for mixed‑flora infections, but alternatives such as macrolides or fluoroquinolones may be chosen based on resistance patterns, patient allergies, and site of infection.

Store Klavobel Bid at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain stability. Do not use if the packaging is damaged or the product appears discoloured.

Klavobel Bid is taken orally, usually with a full glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal upset. Follow the prescriber’s dosing schedule and complete the full course, even if symptoms improve.

Serious adverse events include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, Clostridioides difficile‑associated colitis, significant liver enzyme elevation, neutropenia, and hemolytic anemia. Patients should seek immediate medical attention if they experience rash, fever, jaundice, persistent diarrhea, or breathing difficulties.

Klavobel Bid is contraindicated in individuals with a known hypersensitivity to amoxicillin, clavulanic acid, or any other β‑lactam antibiotics. Patients with a history of severe allergic reactions to penicillins should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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