Product image of Klazidem (Clarithromycin) supplied by GNH India

Klazidem

Active Ingredient:
Clarithromycin
Origin:
EU

Klazidem (Clarithromycin)

Clarithromycin, the active ingredient in Klazidem, is a macrolide antibiotic presented as an oral dosage form for systemic use. It treats a range of bacterial infections, including respiratory, sinus, and skin infections, and is employed in Helicobacter pylori eradication regimens for adult patients.

GNH India supplies Klazidem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

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Indications & Clinical Uses

Clarithromycin is indicated for several bacterial infection categories, acting primarily on susceptible Gram‑positive and some Gram‑negative organisms.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves clinical outcomes.
  • Acute bacterial sinusitis: reduces sinus inflammation and infection symptoms.
  • Acute bacterial exacerbations of chronic bronchitis: helps restore lung function and decrease sputum production.
  • Skin and soft‑tissue infections: treats cellulitis, erysipelas and other dermal infections.
  • Helicobacter pylori eradication regimens: used in combination therapy to achieve bacterial clearance.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting translocation of the peptidyl‑tRNA. This blocks protein synthesis, leading to a bacteriostatic effect against susceptible organisms and, at higher concentrations, a bactericidal effect. The drug’s activity is concentration‑dependent and targets a broad spectrum of Gram‑positive, some Gram‑negative, and atypical bacteria.

Side Effects

Clarithromycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: loose stools that may be watery.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Altered taste: metallic or bitter sensation.
  • Headache: mild to moderate intensity.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Hepatic failure: rare but life‑threatening liver injury.

Precautions & Warnings

Before prescribing Klazidem, clinicians should consider several safety aspects.

  • Assess liver function: monitor hepatic enzymes in patients with pre‑existing liver disease.
  • Monitor cardiac rhythm: avoid in patients with known QT prolongation or arrhythmias.
  • Avoid use in patients with known macrolide hypersensitivity: discontinue if allergic reaction occurs.
  • Use with caution in renal impairment: dose adjustment may be required.
  • Review concomitant medications: consider potential drug‑drug interactions.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Clarithromycin interacts with several medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Cisapride: may cause serious cardiac arrhythmias.
  • Pimozide: increased plasma concentrations leading to toxicity.
  • Ergot alkaloids: risk of ergotism and severe vasospasm.

Moderate Interactions (Monitor Closely)

  • Statins (simvastatin, lovastatin): heightened risk of myopathy.
  • Warfarin: enhanced anticoagulant effect, monitor INR.
  • Theophylline: increased serum levels, watch for toxicity.

Frequently Asked Questions

Klazidem contains clarithromycin, a macrolide antibiotic used to treat bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing translocation of the peptidyl‑tRNA. This blocks the production of essential proteins, resulting in a bacteriostatic effect that can become bactericidal at higher concentrations.

The prescribed dose of clarithromycin is determined by the treating physician based on the infection type, severity, patient age, renal and hepatic function, and other clinical factors. Dosage regimens vary and should follow the prescriber’s instructions.

Safety data for clarithromycin in pregnancy are limited, and the drug should be used only if the potential benefit justifies any potential risk to the fetus. It is excreted in breast milk; breastfeeding mothers should discuss risks and benefits with their healthcare provider.

To order Klazidem, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Klazidem (clarithromycin) belongs to the macrolide class, similar to azithromycin. Compared with azithromycin, clarithromycin generally has a broader spectrum against certain Gram‑positive organisms and a higher potential for drug‑drug interactions due to CYP3A4 inhibition, while azithromycin often has a longer half‑life and fewer interactions.

Klazidem should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Klazidem is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset. The exact administration schedule should follow the prescribing clinician’s directions.

Serious risks include Clostridioides difficile‑associated diarrhea, hepatotoxicity, QT interval prolongation leading to arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience persistent diarrhea, jaundice, palpitations, or signs of an allergic reaction.

Klazidem is contraindicated in individuals with a known hypersensitivity to clarithromycin, other macrolides, or any component of the formulation. It should also be avoided in patients taking medications that have major interactions, such as cisapride, pimozide, or ergot alkaloids, unless alternative therapy is not possible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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