Product image of Klean-Prep (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 3) supplied by GNH India

Klean-Prep

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 3
Origin:
EU

Klean-Prep (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 3)

Sodium Hydrogen Carbonate, the active ingredient in Klean-Prep, is an oral electrolyte and osmotic agent presented as a powder for oral reconstitution for oral use. It assists in restoring electrolyte balance and facilitating bowel cleansing in adults undergoing diagnostic or therapeutic procedures.
GNH India supplies Klean-Prep as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Norgine Sas

1
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Indications & Clinical Uses

Klean-Prep, containing an electrolyte and osmotic agent blend, is employed in gastrointestinal and electrolyte management.

  • Dehydration: helps replenish sodium, potassium and chloride losses in patients with fluid depletion.
  • Bowel preparation: provides an osmotic effect that promotes intestinal cleansing before colonoscopy or surgery.
  • Acid‑base disorders: contributes to neutralising gastric acidity in conditions requiring alkalinisation.

How It Works

  • Klean-Prep works by delivering a combination of sodium, potassium, chloride and sulfate ions that are readily absorbed in the gastrointestinal tract, thereby correcting electrolyte deficits. The macrogol component creates an osmotic gradient that retains water in the intestinal lumen, promoting stool softening and facilitating bowel evacuation. Together, these actions support fluid balance and gastrointestinal cleansing.

Side Effects

Klean-Prep may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate feeling of stomach upset.
  • Abdominal cramping: transient discomfort during bowel preparation.
  • Diarrhoea: increased loose stools due to osmotic activity.
  • Electrolyte imbalance: mild shifts in sodium or potassium levels.
  • Headache: occasional tension‑type headache.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Hypernatremia: markedly elevated blood sodium concentration.
  • Hypokalemia: low potassium levels that may cause cardiac arrhythmia.
  • Allergic reaction: rash, itching or swelling of the face, lips or tongue.
  • Metabolic acidosis: rare disturbance of blood pH.

Precautions & Warnings

Before using Klean-Prep, consider the following safety measures.

  • Renal impairment: assess kidney function to avoid electrolyte overload.
  • Cardiac disease: monitor patients with heart failure for fluid shifts.
  • Diabetes: watch for changes in blood glucose due to altered fluid balance.
  • Pediatric use: limit to older children under medical supervision.
  • Concomitant diuretics: adjust electrolyte monitoring when used together.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Klean-Prep can interact with other medicines that affect fluid and electrolyte status.

Major Interactions (Avoid)

  • Loop diuretics: may cause severe electrolyte depletion.
  • ACE inhibitors: increased risk of hyperkalemia.
  • Lithium: altered renal clearance can raise lithium levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may impair renal function and affect electrolyte balance.
  • Antacids containing sodium: risk of excessive sodium load.
  • Antihypertensives: potential for blood pressure changes due to fluid shifts.

Frequently Asked Questions

Klean-Prep is an oral powder that provides electrolytes and an osmotic laxative effect. It is commonly used to correct fluid and electrolyte loss, to prepare the bowel before diagnostic procedures such as colonoscopy, and to help neutralise excess gastric acidity.

Sodium Hydrogen Carbonate supplies sodium ions that are absorbed in the gut, helping to restore electrolyte balance and raise systemic pH. Together with potassium chloride, sodium chloride, sodium sulfate and macrogol, it creates an osmotic gradient that draws water into the intestinal lumen, softening stool and promoting bowel evacuation.

The dose of Klean-Prep is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and the intended indication. Healthcare professionals should follow local guidelines and adjust the amount of powder reconstituted and administered accordingly.

Safety data for Klean-Prep in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Klean-Prep combines electrolyte replacement with an osmotic laxative, offering both fluid balance and bowel cleansing in a single formulation. Compared with pure polyethylene glycol solutions, it provides additional sodium and potassium ions, which may reduce the need for separate rehydration fluids, but the overall efficacy and tolerability depend on individual patient factors.

Klean-Prep should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and ensure that the powder is not exposed to extreme humidity which could affect its stability.

The powder is reconstituted with a specified volume of clean water according to the label instructions. The resulting solution is taken orally, usually in divided doses, under the supervision of a healthcare professional who will advise on the timing relative to the intended procedure.

Serious risks include severe dehydration, electrolyte disturbances such as hypernatremia or hypokalemia, and rare allergic reactions. Patients with renal, cardiac or metabolic disorders should be closely monitored, and any signs of severe side effects require immediate medical attention.

Klean-Prep is contraindicated in individuals with known hypersensitivity to any of its components, severe renal impairment, uncontrolled heart failure, or in patients who are unable to tolerate oral intake. It should also be avoided in children under the age recommended by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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