Product image of Klektica (Levofloxacin) supplied by GNH India

Klektica

Active Ingredient:
Levofloxacin
Origin:
EU

Klektica (Levofloxacin)

Levofloxacin, the active ingredient in Klektica, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections, including respiratory tract, urinary tract, skin and soft‑tissue, sinus and prostatitis, primarily in adult patients. It is indicated for adult patients with confirmed bacterial infections and is commonly prescribed when susceptibility testing supports its use.

GNH India supplies Klektica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, sourcing the product from EU‑regulated manufacturers and adhering to stringent quality and regulatory standards.

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum fluoroquinolone that targets bacterial DNA replication, making it useful for several infection types.

  • Respiratory tract infections: effective in treating community‑acquired pneumonia, acute bacterial sinusitis and bronchitis.
  • Urinary tract infections: clears uncomplicated and complicated UTIs caused by susceptible organisms.
  • Skin and soft‑tissue infections: resolves cellulitis, wound infections and abscesses.
  • Sinusitis: provides rapid bacterial eradication in acute sinus infections.
  • Prostatitis: treats bacterial prostatitis and reduces symptom recurrence.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for supercoiling and separation of DNA during replication and transcription. By binding to the ATP‑binding sites of these enzymes, it prevents relaxation of DNA strands, halting bacterial cell division and leading to bacterial death. This bactericidal action is concentration‑dependent and covers a wide range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • QT interval prolongation leading to arrhythmia
  • Severe allergic reactions such as anaphylaxis

Precautions & Warnings

When prescribing Levofloxacin, clinicians should consider several safety precautions to minimize risk.

  • Assess renal function: dose adjustment may be required in impaired clearance.
  • Avoid in patients with known tendon disorders: risk of tendonitis or rupture.
  • Monitor cardiac status: watch for QT prolongation, especially with other QT‑prolonging agents.
  • Use with caution in pregnancy or breastfeeding: safety category is unknown, weigh benefits versus risks.
  • Review concomitant medications: check for potential drug‑drug interactions that may increase toxicity.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increased risk of tendon rupture.
  • QT‑prolonging drugs (e.g., quinidine, moxifloxacin): additive effect on cardiac repolarisation.
  • Antacids or supplements containing aluminum, magnesium, calcium, or iron: markedly reduce levofloxacin absorption.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: combined use may heighten tendon injury risk.
  • Diabetes medications (e.g., insulin, sulfonylureas): possible hyperglycaemia.
  • Theophylline: levofloxacin may raise plasma theophylline concentrations.

Frequently Asked Questions

Klektica contains levofloxacin, a fluoroquinolone antibiotic used to treat bacterial infections such as community‑acquired pneumonia, acute sinusitis, urinary tract infections, skin and soft‑tissue infections, and bacterial prostatitis in adult patients.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, it prevents bacterial cell division and leads to bacterial death, providing a bactericidal effect against a broad range of pathogens.

The prescribed dose of Klektica is set by the treating clinician based on the type and severity of infection, patient age, weight, renal function, and local susceptibility patterns. No fixed regimen is provided here; the prescriber tailors therapy to each individual case.

Levofloxacin’s pregnancy category is listed as unknown, and safety data are limited. It should only be used during pregnancy or lactation when the potential benefit outweighs the potential risk, and after careful consideration by the prescribing healthcare professional.

To order Klektica, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klektica (levofloxacin) is a third‑generation fluoroquinolone with a broad spectrum covering many Gram‑negative and Gram‑positive bacteria. Compared with older agents like ciprofloxacin, levofloxacin often offers once‑daily dosing and enhanced activity against respiratory pathogens, though safety considerations such as tendon risk remain similar across the class.

Klektica tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children to maintain product stability and potency.

Klektica is taken orally, usually with a full glass of water. It may be taken with or without food, but antacids or mineral supplements should be spaced at least two hours apart to avoid reduced absorption. Patients should follow the prescriber’s instructions regarding timing and duration.

Serious adverse events linked to Klektica include tendon rupture or inflammation, QT‑interval prolongation that can lead to arrhythmias, and severe hypersensitivity reactions such as anaphylaxis. Prompt medical attention is required if patients experience sudden tendon pain, palpitations, or signs of an allergic reaction.

Klektica should be avoided in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval unless benefits clearly outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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