Product image of Kleodina (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Kleodina

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Kleodina (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol and Levonorgestrel, the active ingredients in Kleodina, are a combined oral contraceptive presented as a tablet for oral use. The formulation works by preventing ovulation and creating conditions unfavorable for fertilisation, providing reliable pregnancy prevention for women of reproductive age.

GNH India supplies Kleodina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets. The product conforms to European Union pharmaceutical standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Gedeon Richter Plc.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Kleodina, a combined oral contraceptive, is used within the hormonal contraception pathway to prevent pregnancy.

  • Pregnancy prevention: Provides reliable contraception for women of reproductive age.
  • Menstrual cycle regulation: Helps achieve more regular and predictable menstrual bleeding.
  • Treatment of acne related to androgen excess: Reduces skin lesions by modulating hormonal levels.

How It Works

  • Ethinylestradiol and levonorgestrel bind to estrogen and progesterone receptors, respectively, suppressing the hypothalamic‑pituitary‑ovarian axis. This inhibition reduces the release of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), preventing follicular development and ovulation. The progestin component also thickens cervical mucus and induces endometrial changes that hinder implantation.

Side Effects

Kleodina may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: Mild to moderate stomach upset.
  • Breast tenderness: Temporary discomfort or swelling.
  • Headache: Occasional mild to moderate pain.
  • Spotting or breakthrough bleeding: Irregular light bleeding.
  • Mood changes: Fluctuations in emotional state.
  • Weight gain: Slight increase in body weight.

Serious or Rare Side Effects

  • Deep vein thrombosis: Blood clot formation in deep veins.
  • Pulmonary embolism: Clot migration to lung vessels.
  • Stroke: Disruption of cerebral blood flow.
  • Myocardial infarction: Heart attack due to blocked coronary arteries.
  • Severe allergic reaction: Anaphylaxis with rash, swelling, or breathing difficulty.
  • Liver tumor: Benign hepatic adenoma in rare cases.

Precautions & Warnings

Before prescribing Kleodina, clinicians should consider several safety aspects.

  • Cardiovascular risk assessment: Evaluate history of thromboembolic events.
  • Smoking status: Advise against use in women over 35 who smoke.
  • Liver function: Check for hepatic impairment before initiation.
  • Pregnancy and lactation: Avoid use during pregnancy; discuss breastfeeding considerations.
  • Drug interaction review: Assess concomitant medications that may affect efficacy.
  • Store at ambient temperature: Keep tablets in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Kleodina can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): May markedly reduce contraceptive efficacy.
  • Anticoagulants (e.g., warfarin): May increase INR and bleeding risk.
  • Certain antiretrovirals (e.g., efavirenz): Can lower hormone levels.

Moderate Interactions (Monitor Closely)

  • Antibiotics such as tetracycline: May slightly decrease absorption.
  • Herbal supplements (e.g., St. John's wort): Potential reduction in effectiveness.
  • Antihypertensives: May cause modest blood pressure elevation.

Frequently Asked Questions

Kleodina is a combined oral contraceptive containing ethinylestradiol and levonorgestrel. It is prescribed to prevent pregnancy in women of reproductive age and may also be used to regulate menstrual cycles and treat hormone‑related acne.

The ethinylestradiol component provides estrogenic activity, while levonorgestrel supplies progestogenic effects. Together they suppress the hypothalamic‑pituitary‑ovarian axis, inhibiting LH and FSH release, which prevents ovulation. The progestin also thickens cervical mucus and alters the endometrium, creating an environment unsuitable for fertilisation and implantation.

The dosing regimen for Kleodina is determined by the prescribing healthcare professional. Typically, it is taken once daily at the same time for a 21‑day active phase followed by a hormone‑free interval, but exact instructions must be provided by the prescriber.

Kleodina is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the product should be stopped immediately. Regarding breastfeeding, clinicians should evaluate the risk‑benefit ratio, as hormonal contraceptives can affect milk production and infant exposure.

To order Kleodina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details and any necessary import documentation.

Kleodina contains the standard dose combination of ethinylestradiol and levonorgestrel, a widely used progestin. Compared with pills that use newer progestins, Kleodina offers a well‑characterised efficacy and safety profile, but individual tolerability may differ. Choice of formulation often depends on patient‑specific factors such as side‑effect sensitivity and drug‑interaction risk.

Kleodina tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat and direct sunlight. Keep out of reach of children and do not use after the expiration date printed on the label.

Kleodina is taken orally, usually as a single tablet each day at the same time. A typical cycle consists of 21 consecutive active tablets followed by a 7‑day hormone‑free interval during which withdrawal bleeding occurs. Patients should follow the specific instructions provided by their prescriber.

The most serious risks include thromboembolic events such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. Rarely, severe allergic reactions or hepatic adenomas may occur. Patients should seek immediate medical attention if they experience unexplained leg pain, chest discomfort, severe headache, or signs of an allergic reaction.

Kleodina is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or those who are pregnant. It should also be avoided by smokers over 35 years of age and by individuals taking medications that significantly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.