Product image of Klikedi (Diclofenac Sodium) supplied by GNH India

Klikedi

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Klikedi (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Klikedi, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical gel for cutaneous use. It relieves musculoskeletal pain and inflammation in adults.

GNH India supplies Klikedi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Inspharma D.O.O.

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Indications & Clinical Uses

Diclofenac sodium is used topically to manage pain and inflammation in the musculoskeletal system.

  • Musculoskeletal pain: provides localized relief of pain and swelling.
  • Osteoarthritis (knee): reduces joint pain and improves mobility.
  • Rheumatoid arthritis (hand joints): alleviates inflammation and discomfort.

How It Works

  • Diclofenac sodium inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, it produces a localized anti‑inflammatory and analgesic effect without substantial systemic exposure.

Side Effects

Topical diclofenac may cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects

  • Skin irritation: mild burning or stinging at the application site.
  • Redness: localized erythema.
  • Itching: pruritus around the treated area.
  • Dry skin: occasional desquamation.
  • Rash: transient maculopapular eruption.
  • Pruritic papules: small raised lesions.

Serious or Rare Side Effects

  • Allergic reactions: angioedema or anaphylaxis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Photosensitivity: exaggerated sunburn response.
  • Systemic NSAID effects: gastrointestinal ulceration or bleeding.
  • Renal impairment: reduced kidney function with extensive use.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

When using topical diclofenac, consider the following safety measures.

  • Pregnancy: avoid use in the third trimester due to potential fetal risk.
  • Breastfeeding: exercise caution; diclofenac may be excreted in milk.
  • Skin integrity: do not apply to broken, infected, or irritated skin.
  • Concomitant NSAIDs: avoid simultaneous systemic NSAID therapy to reduce additive toxicity.
  • Renal or hepatic impairment: use with medical supervision and monitor function.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac sodium can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and cardiovascular toxicity.
  • Lithium: elevated serum lithium levels.

Moderate Interactions (Monitor Closely)

  • Methotrexate: enhanced methotrexate toxicity.
  • ACE inhibitors or diuretics: possible reduction in renal function, especially in dehydrated patients.

Frequently Asked Questions

Klikedi is a topical formulation containing diclofenac sodium that is applied to the skin to relieve pain and reduce inflammation associated with musculoskeletal conditions such as joint pain, osteoarthritis, and rheumatoid arthritis.

Diclofenac sodium inhibits cyclooxygenase enzymes (COX‑1 and COX‑2) in peripheral tissues, which lowers prostaglandin production. This reduction diminishes the inflammatory response and provides localized analgesic effects at the site where the gel is applied.

The appropriate amount of Klikedi to apply is determined by the prescribing healthcare professional based on the specific condition, severity, and patient characteristics. Patients should follow the prescriber’s instructions and not exceed the recommended application frequency.

Safety data for topical diclofenac in pregnancy are limited, and use is generally avoided in the third trimester. Caution is advised during breastfeeding because diclofenac can be excreted in breast milk. Consultation with a healthcare provider is essential before use.

To request Klikedi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Klikedi delivers diclofenac directly to the skin, offering targeted pain relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal and cardiovascular side effects, making it a preferred option for patients needing localized therapy.

Klikedi should be stored at room temperature, preferably below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain its stability and efficacy.

Klikedi is applied topically to clean, dry skin over the affected area. The prescribed amount is spread in a thin layer and gently massaged until absorbed. Hands should be washed after application, and the treated area should not be covered with occlusive dressings unless directed by a clinician.

Serious risks include severe allergic reactions such as angioedema, rare but life‑threatening skin conditions like Stevens‑Johnson syndrome, and systemic NSAID effects including gastrointestinal bleeding, renal impairment, and cardiovascular events, especially with extensive use or in high‑risk patients.

Klikedi should not be used by individuals with known hypersensitivity to diclofenac or any component of the formulation, by patients with active skin infections or open wounds at the application site, and by those in the third trimester of pregnancy. Consultation with a healthcare professional is required for other contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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