Product image of Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent) supplied by GNH India

Klimadynon

Active Ingredient:
Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent
Origin:
EU

Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent)

Dry Extract From Cimicifuga Racemosa (Black Cohosh), the active ingredient in Klimadynon, is a herbal botanical presented as a standardized dry extract for oral use. It is derived from the rhizome of the black cohosh plant and is traditionally employed to help alleviate menopausal discomforts such as hot flashes, night sweats, and mood changes in adult women.

GNH India supplies Klimadynon as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across global markets.

Manufacturer / TM Owner

Bionorica Se

1
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Indications & Clinical Uses

Klimadynon, a black cohosh dry extract, is used to support women experiencing menopausal symptoms.

  • Menopausal hot flashes: may reduce the frequency and intensity of hot flashes.
  • Night sweats: may lessen excessive nighttime sweating.
  • Mood swings: may help improve mood stability during menopause.

How It Works

  • The dry extract contains phytochemicals such as triterpene glycosides, flavonoids, and phenolic acids that interact with serotonergic and dopaminergic pathways in the central nervous system, modulating neurotransmitter activity and influencing thermoregulatory centers. This multimodal action is thought to alleviate vasomotor symptoms associated with estrogen deficiency.

Side Effects

Adverse reactions have been reported with oral black cohosh extracts. Most are mild and reversible.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient episodes.
  • Skin rash: mild erythema or itching.
  • Fatigue: occasional tiredness.

Serious or Rare Side Effects

  • Liver injury: signs of hepatitis or elevated enzymes.
  • Severe allergic reaction: anaphylaxis, swelling of face or throat.
  • Blood clot formation: deep vein thrombosis.
  • Severe hypertension: sudden increase in blood pressure.
  • Acute pancreatitis: abdominal pain with elevated enzymes.

Precautions & Warnings

Safety considerations should be observed before and during therapy.

  • Assess liver function: monitor hepatic enzymes before initiating and periodically during use.
  • Avoid in known hypersensitivity: discontinue if rash or swelling develops.
  • Caution in hormone‑sensitive conditions: evaluate risk in patients with breast or uterine cancer.
  • Do not use during pregnancy: insufficient safety data for fetal exposure.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Potential drug‑herb interactions may modify therapeutic outcomes.

Major Interactions (Avoid)

  • Concurrent use with hormonal contraceptives: may reduce contraceptive efficacy.
  • Combination with anticoagulants (e.g., warfarin): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Use with SSRIs or SNRIs: possible additive serotonergic effects.
  • Use with CYP450 substrates: potential alteration of drug metabolism.
  • Use with other herbal supplements: risk of additive side‑effects or pharmacodynamic overlap.

Frequently Asked Questions

Klimadynon is a standardized dry extract of black cohosh that is used to support women experiencing menopausal symptoms such as hot flashes, night sweats, and mood changes. It is classified as a herbal botanical and is taken orally under the guidance of a healthcare professional.

The extract contains a mixture of phytochemicals that interact with serotonergic and dopaminergic pathways in the central nervous system. By modulating neurotransmitter activity and influencing thermoregulatory centers, the extract helps to reduce vasomotor disturbances that are common during menopause.

The appropriate dose of Klimadynon is determined by the prescribing clinician based on individual patient factors, including severity of symptoms and overall health status. No fixed regimen is provided here; patients should follow the dosage instructions given by their healthcare provider.

There is insufficient clinical data to confirm safety of black cohosh extracts during pregnancy or lactation. Consequently, Klimadynon is generally not recommended for pregnant or breastfeeding women, and a healthcare professional should be consulted before use in these populations.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Klimadynon offers a plant‑based alternative that targets menopausal vasomotor symptoms without providing systemic estrogen. Unlike HRT, it does not replace deficient hormones, so it may have a different risk profile, particularly regarding thrombotic and breast‑cancer concerns. Clinical decisions should weigh efficacy, safety, patient preference and medical history.

Klimadynon should be stored at room temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme heat to maintain potency and stability throughout its shelf life.

Klimadynon is taken orally, usually with a glass of water. The tablet or capsule should be swallowed whole and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious adverse events, although rare, can include liver injury, severe allergic reactions such as anaphylaxis, and the formation of blood clots. Patients should seek immediate medical attention if they experience signs of hepatitis, swelling of the face or throat, or unexplained leg pain and swelling.

Klimadynon should be avoided by individuals with known hypersensitivity to black cohosh, pregnant or breastfeeding women, and patients with hormone‑sensitive cancers such as breast or uterine carcinoma. Anyone with a history of severe liver disease should also consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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