Product image of Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent) supplied by GNH India

Klimadynon

Active Ingredient:
Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent
Origin:
EU

Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent)

Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent, the active ingredient in Klimadynon, is a herbal botanical presented as an oral extract for oral use. It is used to relieve menopausal symptoms in women, including hot flashes, night sweats and mood changes.

GNH India supplies Klimadynon as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for healthcare providers across multiple regions.

Manufacturer / TM Owner

Bionorica Se

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Indications & Clinical Uses

Klimadynon, a black cohosh extract, is used to address menopausal symptom relief.

  • Menopausal hot flashes: may reduce frequency and intensity of sudden warmth episodes.
  • Night sweats: can lessen nighttime perspiration and improve sleep quality.
  • Mood swings: may help stabilize emotional fluctuations associated with hormonal changes.
  • Vaginal dryness: may improve comfort by supporting mucosal moisture.
  • Overall quality of life: may contribute to improved well‑being during menopause.

How It Works

  • The exact mechanism of black cohosh is not fully elucidated, but the extract is thought to interact with serotonergic (5‑HT1A/5‑HT7) receptors and modulate central neurotransmission, as well as exert weak estrogenic activity on peripheral tissues. These actions may influence thermoregulatory pathways in the hypothalamus and affect mood‑regulating circuits, contributing to relief of vasomotor and emotional menopausal symptoms.

Side Effects

Klimadynon may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Gastrointestinal upset: mild nausea, abdominal discomfort or diarrhea.
  • Headache: transient dull or throbbing pain.
  • Dizziness: occasional light‑headedness.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Liver injury: signs of hepatitis or elevated liver enzymes.
  • Severe allergic reaction: anaphylaxis, swelling of face or throat.
  • Hypertensive crisis: sudden increase in blood pressure.
  • Thromboembolic events: rare clot formation.

Precautions & Warnings

Before using Klimadynon, consider the following precautions to ensure safe and appropriate use.

  • Consult healthcare professional: especially if you are taking hormone therapy or have liver disease.
  • Avoid if hypersensitive: do not use if you have known allergy to black cohosh or related plants.
  • Monitor liver function: report any signs of jaundice, dark urine or abdominal pain.
  • Pregnancy and breastfeeding: safety has not been established; avoid use during these periods.
  • Drug interactions: discuss all concurrent medications with your provider to assess potential interactions.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct light.

Avoid Interactions

Klimadynon can interact with certain medicines; awareness of these interactions helps minimize risk.

Major Interactions (Avoid)

  • Combined estrogen therapy: may increase estrogenic effects and risk of side‑effects.
  • Hepatotoxic drugs: concurrent use may heighten risk of liver injury.
  • Strong CYP450 inhibitors: could alter the metabolism of black cohosh constituents.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs/SNRIs): possible additive serotonergic activity leading to serotonin syndrome.
  • Blood pressure medications: black cohosh may affect blood pressure control, requiring monitoring.

Frequently Asked Questions

Klimadynon is an oral herbal product containing a dry extract of Cimicifuga racemosa (black cohosh). It is primarily used to alleviate common menopausal symptoms such as hot flashes, night sweats, mood swings, and vaginal dryness, helping women achieve greater comfort during the transition.

The black cohosh extract is believed to act on serotonergic receptors in the brain and to exhibit weak estrogen‑like activity in peripheral tissues. These actions may modulate the hypothalamic thermoregulatory centre and influence mood pathways, which together contribute to reduced vasomotor symptoms and emotional fluctuations.

The appropriate dose of Klimadynon is determined by a qualified healthcare professional based on individual needs, severity of symptoms, and any concurrent therapies. Patients should follow the prescriber’s instructions and not adjust the dosage without medical guidance.

Safety of black cohosh extracts, including Klimadynon, has not been established for pregnant or lactating women. Current recommendations advise avoiding use during pregnancy and breastfeeding unless a healthcare provider determines that the potential benefits outweigh the uncertain risks.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Klimadynon offers a botanical alternative to hormone replacement therapy (HRT) and synthetic pharmaceuticals. While HRT directly replaces estrogen, black cohosh provides a milder, plant‑based approach with a different safety profile. Choice of therapy should be individualized, considering efficacy, side‑effect risk, personal preference and medical history.

Store Klimadynon at room temperature, ideally below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the lid is tightly closed to maintain stability throughout its shelf life.

Klimadynon is taken orally, usually in tablet or capsule form, as directed by a healthcare professional. The product should be swallowed with water and taken with or without food according to the prescriber’s guidance.

Although uncommon, serious adverse events can include liver injury manifested by jaundice or elevated liver enzymes, severe allergic reactions such as anaphylaxis, and rare cardiovascular events like hypertensive crises. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to black cohosh or related plant species, those taking hepatotoxic medications, pregnant or breastfeeding women, and patients with uncontrolled liver disease should avoid Klimadynon unless a physician determines it is appropriate after careful risk assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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