Product image of Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent) supplied by GNH India

Klimadynon

Active Ingredient:
Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent
Origin:
EU

Klimadynon (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent)

Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh), the active ingredient in Klimadynon, is a herbal botanical presented as a botanical extract for oral use. It is traditionally employed to support relief of menopausal symptoms such as hot flashes, night sweats and mood changes.

GNH India supplies Klimadynon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bionorica Se

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Indications & Clinical Uses

Klimadynon is a botanical extract that acts on hormonal and thermoregulatory pathways associated with menopause.

  • Menopausal hot flashes: reduces frequency and intensity of sudden warmth episodes.
  • Night sweats: alleviates excessive nocturnal perspiration.
  • Mood swings during menopause: supports emotional balance.
  • Menopausal insomnia: may improve sleep quality.
  • Mild menstrual discomfort: can lessen cramping and discomfort.

How It Works

  • The black cohosh extract contains triterpene glycosides, phenolic acids and flavonoids that modulate serotonergic (5‑HT1A) receptors and exhibit weak estrogenic activity at peripheral tissues. These actions influence hypothalamic thermoregulation and neuroendocrine pathways, helping to stabilize vasomotor symptoms and mood fluctuations associated with menopause.

Side Effects

Adverse reactions reported with black cohosh extracts vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: mild nausea or abdominal discomfort.
  • Headache: transient dull or throbbing pain.
  • Dizziness: occasional light‑headed sensation.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver injury such as jaundice or elevated enzymes.
  • Allergic anaphylaxis: rapid swelling, breathing difficulty, or hives.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Severe hypertension: sudden increase in blood pressure.

Precautions & Warnings

When considering Klimadynon, certain safety measures are recommended.

  • Pregnancy: avoid unless specifically prescribed by a qualified health professional.
  • Breastfeeding: use with caution; limited data on infant exposure.
  • Pre‑existing liver disease: monitor hepatic function regularly.
  • Hormone‑sensitive conditions: assess risk‑benefit before use.
  • Concomitant medications: review potential interactions with other therapies.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Klimadynon may interact with other agents that affect hormonal or metabolic pathways.

Major Interactions (Avoid)

  • Hormone replacement therapy (estrogen): may amplify estrogenic effects.
  • Anticoagulants (e.g., warfarin): could increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may alter serotonergic activity.
  • Strong CYP450 inhibitors (e.g., ketoconazole): may affect extract metabolism.
  • Other herbal estrogenic supplements (e.g., soy isoflavones): potential additive hormonal effects.

Frequently Asked Questions

Klimadynon is a herbal botanical containing black cohosh extract that is used to support the relief of menopausal symptoms such as hot flashes, night sweats, sleep disturbances and mood swings. It is taken orally under the direction of a health‑care professional.

The extract contains triterpene glycosides and phenolic compounds that act on serotonergic receptors and exhibit weak estrogenic activity. These actions help modulate the hypothalamic pathways that control body temperature and mood, thereby reducing vasomotor symptoms associated with menopause.

The appropriate dose of Klimadynon is determined by the prescribing clinician based on individual health status, severity of symptoms and any concomitant therapies. Patients should follow the specific instructions provided by their health‑care professional.

Klimadynon is generally not recommended for use during pregnancy or while breastfeeding unless a qualified health‑care provider explicitly advises otherwise. Limited safety data are available for these populations, so caution is advised.

To order Klimadynon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with conventional hormone replacement therapy, Klimadynon offers a non‑hormonal botanical option that may have a different side‑effect profile. It does not contain synthetic hormones, making it an alternative for patients seeking plant‑based support, though efficacy and safety should be evaluated individually.

Klimadynon should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to extreme temperatures.

Klimadynon is administered orally, typically as a capsule or tablet, according to the dosage prescribed by a health‑care professional. It should be taken with water and may be taken with or without food as directed.

The most serious risks include rare cases of liver injury, severe allergic reactions such as anaphylaxis, and, very rarely, severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of liver dysfunction, rash, swelling or breathing difficulties.

Individuals with known hypersensitivity to black cohosh, those with active liver disease, pregnant or breastfeeding women (unless advised by a clinician), and patients taking medications that have major interactions—such as estrogen‑based hormone therapy or anticoagulants—should avoid using Klimadynon unless cleared by a health‑care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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