Product image of Klimurtan (Bosentan) supplied by GNH India

Klimurtan

Active Ingredient:
Bosentan
Origin:
EU

Klimurtan (Bosentan)

Bosentan, the active ingredient in Klimurtan, is an endothelin receptor antagonist presented as an oral tablet for oral administration. It works by blocking endothelin receptors to cause vasodilation of pulmonary vessels, and is indicated for the treatment of pulmonary arterial hypertension in adult patients.

GNH India supplies Klimurtan as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide. The company ensures quality compliance with EU standards and reliable global distribution. All shipments are handled under strict temperature‑controlled conditions where required.

Manufacturer / TM Owner

Elpen Pharmaceutical Co. Inc.

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Indications & Clinical Uses

Klimurtan (bosentan) acts on the endothelin pathway to manage pulmonary arterial hypertension.

  • Idiopathic pulmonary arterial hypertension: improves exercise capacity and delays disease progression.
  • Heritable pulmonary arterial hypertension: reduces pulmonary vascular resistance and enhances functional class.
  • Pulmonary arterial hypertension associated with connective tissue disease: improves hemodynamics and patient symptoms.

How It Works

  • Bosentan exerts its therapeutic effect by competitively binding to both endothelin‑A (ETA) and endothelin‑B (ETB) receptors on vascular smooth‑muscle cells. This dual antagonism blocks the potent vasoconstrictor endothelin‑1, leading to relaxation of pulmonary arteries, decreased pulmonary vascular resistance, and improved cardiac output in patients with pulmonary arterial hypertension.

Side Effects

Bosentan may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain often reported during treatment.
  • Peripheral edema: swelling of the lower extremities.
  • Flushing: transient redness of the skin.
  • Nasal congestion: stuffy nose or runny nose.
  • Fatigue: feeling of tiredness or lack of energy.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury requiring monitoring.
  • Anemia: reduction in red blood cell count leading to fatigue.
  • Pulmonary edema: fluid accumulation in lungs, potentially life‑threatening.
  • Severe hypotension: marked drop in blood pressure causing dizziness.

Precautions & Warnings

Before prescribing bosentan, clinicians should consider several safety measures and monitoring requirements.

  • Liver function monitoring: check ALT, AST, bilirubin before and during therapy.
  • Hemoglobin assessment: monitor for anemia regularly.
  • Contraindication in pregnancy: avoid use as it is teratogenic (Category X).
  • Severe hepatic impairment: do not use in patients with significant liver disease.
  • Drug interaction with glyburide: avoid co‑administration due to increased hypoglycemia risk.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Bosentan interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase bosentan plasma concentrations and risk of toxicity.
  • Glyburide: concurrent use can cause severe hypoglycemia.
  • Combined endothelin antagonists: additive risk of liver injury.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce bosentan effectiveness.
  • Amiodarone: may increase bosentan levels modestly.
  • Hormonal contraceptives: bosentan may lower their efficacy, requiring alternative contraception.

Frequently Asked Questions

Klimurtan contains bosentan, which is prescribed for the treatment of pulmonary arterial hypertension (PAH). It helps lower pulmonary arterial pressure, improves exercise capacity, and slows disease progression in adult patients with this serious cardiovascular condition.

Bosentan works by blocking both endothelin‑A and endothelin‑B receptors on the smooth muscle of pulmonary arteries. This dual antagonism prevents endothelin‑1‑mediated vasoconstriction, leading to relaxation of the vessels, reduced pulmonary vascular resistance, and better blood flow through the lungs.

The dosage of bosentan is individualized by the prescribing clinician based on the patient’s condition, response, and laboratory monitoring. Typical regimens start at a standard dose, but the exact amount and schedule must be determined by a qualified healthcare professional.

Bosentan is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as the drug may be excreted in breast milk and affect the infant.

To order Klimurtan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Bosentan belongs to the endothelin receptor antagonist class, whereas other PAH therapies include phosphodiesterase‑5 inhibitors (e.g., sildenafil) and soluble guanylate cyclase stimulators (e.g., riociguat). Bosentan targets endothelin pathways directly, offering an alternative mechanism, but selection depends on patient profile, comorbidities, and physician judgment.

Klimurtan tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Klimurtan is taken orally as a tablet, usually with food to improve absorption and reduce gastrointestinal discomfort. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare provider.

The most serious risks associated with bosentan include hepatotoxicity (elevated liver enzymes or liver injury), anemia, and rare cases of pulmonary edema or severe hypotension. Regular monitoring of liver function tests and hemoglobin levels is essential to detect these adverse events early.

Bosentan should not be used by pregnant women, individuals with severe hepatic impairment, or patients who are concurrently taking glyburide. It is also contraindicated in patients with known hypersensitivity to bosentan or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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