Product image of Klindamycin Evolan (Clindamycin) supplied by GNH India

Klindamycin Evolan

Active Ingredient:
Clindamycin
Origin:
EU

Klindamycin Evolan (Clindamycin)

Clindamycin, the active ingredient in Klindamycin Evolan, is a lincosamide antibiotic presented as a vaginal formulation for intravaginal use. It is employed to treat bacterial vaginosis in women of reproductive age, targeting anaerobic bacteria that cause the infection.

GNH India supplies Klindamycin Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and reliable logistics for global distribution. The company adheres to stringent manufacturing practices and provides regulatory documentation to support import and clinical use.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Clindamycin is a lincosamide antibiotic used to treat infections of the vaginal microbiota.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic bacteria responsible for the condition

How It Works

  • Clindamycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This blockade prevents peptide chain elongation, halting bacterial growth and leading to a bacteriostatic effect against susceptible anaerobic and Gram‑positive organisms.

Side Effects

Clindamycin may cause a range of adverse reactions, from mild irritation to serious systemic events.

Common Side Effects

  • Vaginal irritation or burning sensation
  • Increased vaginal discharge or itching
  • Nausea or mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis
  • Clostridioides difficile‑associated colitis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before prescribing Klindamycin Evolan, clinicians should consider several safety measures.

  • Allergy assessment: confirm no known hypersensitivity to clindamycin or other lincosamides
  • Indication verification: use only for confirmed bacterial vaginosis
  • Monitor for C. difficile: watch for persistent diarrhea or colitis symptoms
  • Hepatic function: exercise caution in patients with liver impairment
  • Drug interactions: review concomitant medications for potential interactions
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct light

Avoid Interactions

Clindamycin can interact with several drug classes, affecting efficacy or safety.

Major Interactions (Avoid)

  • Erythromycin or other macrolides: increased risk of gastrointestinal toxicity
  • Neuromuscular blocking agents: potentiation of muscle weakness
  • Warfarin: possible enhancement of anticoagulant effect

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced hormonal efficacy, advise backup contraception
  • Azole antifungals (e.g., fluconazole): may increase clindamycin plasma levels
  • Rifampin: may decrease clindamycin concentrations, reducing therapeutic effect

Frequently Asked Questions

Klindamycin Evolan is a prescription vaginal formulation of clindamycin indicated for the treatment of bacterial vaginosis. It targets the anaerobic bacteria that disrupt normal vaginal flora, helping to restore a healthy microbial balance.

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This prevents peptide chain elongation, resulting in a bacteriostatic effect that stops the growth of susceptible anaerobic and Gram‑positive organisms.

The dosage and duration of Klindamycin Evolan are set by the prescribing clinician based on the severity of infection, patient weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Safety data for clindamycin in pregnancy and lactation are limited, and the product carries an unknown pregnancy category. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when appropriate.

To request Klindamycin Evolan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clindamycin is a lincosamide that offers strong activity against anaerobic bacteria, often used when metronidazole is contraindicated or ineffective. Compared with metronidazole, clindamycin may have a higher risk of gastrointestinal side effects but can be preferable for patients with metronidazole intolerance.

Store Klindamycin Evolan at temperatures below 25 °C in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Klindamycin Evolan is applied intravaginally as directed by the prescriber, typically using a pre‑filled applicator. The patient should insert the medication into the vagina and retain it for the prescribed period, usually before bedtime to maximize local exposure.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they develop rash, fever, persistent diarrhea or breathing difficulties.

Individuals with a known hypersensitivity to clindamycin, lincomycin or other lincosamide antibiotics should avoid this product. It is also contraindicated in patients with a history of severe colitis or those who have experienced serious adverse reactions to clindamycin previously.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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