Product image of Kliogest N (Norethisterone Acetate, Estradiol) supplied by GNH India

Kliogest N

Active Ingredient:
Norethisterone Acetate, Estradiol
Origin:
EU

Kliogest N (Norethisterone Acetate, Estradiol)

Norethisterone acetate, the active ingredient in Kliogest N, is a combined estrogen‑progestogen presented as an oral tablet for oral use. It contains both norethisterone acetate and estradiol, providing synergistic hormonal activity. It is indicated for contraception and regulation of menstrual cycles in women of reproductive age.

GNH India supplies Kliogest N as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities for bulk manufacturing, quality assurance, and regulatory compliance, and timely delivery to global markets.

Manufacturer / TM Owner

Novo Nordisk Pharma Gmbh

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Indications & Clinical Uses

  • Kliogest N, a combined estrogen‑progestogen oral contraceptive, is used to manage reproductive hormone‑related conditions.
  • Contraception: provides reliable prevention of pregnancy when taken as prescribed.
  • Menstrual cycle regulation: helps achieve regular menstrual bleeding patterns.
  • Management of menstrual disorders: reduces heavy menstrual bleeding and dysmenorrhea.

How It Works

  • Kliogest N works by delivering both norethisterone acetate, a progestogenic agent, and estradiol, an estrogen. The combination suppresses the hypothalamic‑pituitary‑ovarian axis, inhibiting the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, thereby preventing ovulation. In addition, the progestogen thickens cervical mucus and the estrogen stabilises the endometrial lining, creating an environment unfavorable for fertilisation and implantation.

Side Effects

Like all hormonal contraceptives, Kliogest N may cause adverse reactions.

Common Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Spotting between periods

Serious or Rare Side Effects

  • Venous thromboembolism (deep vein thrombosis, pulmonary embolism)
  • Arterial thrombosis (stroke, myocardial infarction)
  • Severe liver dysfunction or jaundice

Precautions & Warnings

  • Before prescribing Kliogest N, clinicians should consider several precautionary measures.
  • Cardiovascular assessment: evaluate history of thromboembolic events, hypertension, or smoking.
  • Liver function: avoid use in patients with active liver disease or abnormal liver enzymes.
  • Smoking status: contraindicated in women over 35 who smoke cigarettes.
  • Medication review: assess concomitant use of strong enzyme inducers that may reduce efficacy.
  • Store at room temperature: keep tablets in original packaging, protect from moisture and light.

Avoid Interactions

Kliogest N can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin): may markedly reduce contraceptive efficacy.
  • Certain antiretroviral agents (e.g., efavirenz, nevirapine): can decrease hormone levels and increase pregnancy risk.
  • Hormonal therapies for breast cancer (e.g., tamoxifen): may counteract contraceptive action.

Moderate Interactions (Monitor Closely)

  • Antibiotics and antifungals (e.g., macrolides, ketoconazole): may modestly lower hormone concentrations.
  • St. John’s wort: can reduce contraceptive effectiveness, requiring additional barrier methods.
  • Grapefruit juice: may affect hormone metabolism, warranting monitoring.

Frequently Asked Questions

Kliogest N is a combined estrogen‑progestogen oral contraceptive indicated for reliable prevention of pregnancy and for regulation of menstrual cycles. It is also prescribed to manage menstrual disorders such as heavy bleeding and dysmenorrhea in women of reproductive age.

The formulation delivers norethisterone acetate, a progestogen, together with estradiol, an estrogen. The pair suppresses the hypothalamic‑pituitary‑ovarian axis, preventing the luteinising hormone surge that triggers ovulation. Additionally, the progestogen thickens cervical mucus while the estrogen stabilises the endometrial lining, reducing the chance of fertilisation and implantation.

The specific dosing regimen for Kliogest N is determined by the prescribing healthcare professional. Typically, the product is taken as one tablet daily at the same time each day, but the exact schedule and duration should follow the prescriber’s instructions.

Kliogest N is contraindicated during pregnancy because it is intended to prevent conception. Women who become pregnant should discontinue use and seek medical advice. Limited data exist for breastfeeding; therefore, use while nursing should be discussed with a healthcare provider to weigh potential risks and benefits.

To order Kliogest N, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. The sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details and any necessary import documentation.

Kliogest N contains both norethisterone acetate and estradiol, offering a specific estrogen‑to‑progestogen ratio. Compared with other combined oral contraceptives that may use ethinyl estradiol or different progestins, Kliogest N may have a different side‑effect profile and metabolic impact. Choice of product should be individualized based on patient history, risk factors and physician preference.

Store Kliogest N tablets at room temperature, below 25 °C. Keep them in the original packaging to protect from moisture and light, and store out of reach of children. Do not refrigerate or freeze the tablets.

Kliogest N is taken orally as a tablet. It should be swallowed with water at the same time each day, with or without food. Consistent daily intake maintains hormone levels and maximises contraceptive effectiveness.

The most serious risks include thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke or myocardial infarction, especially in women with cardiovascular risk factors. Severe liver dysfunction, jaundice, and allergic reactions are also critical concerns that require immediate medical attention.

Kliogest N is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or those who are pregnant. It should also be avoided by smokers over 35 years of age and by individuals taking strong enzyme‑inducing medications that reduce contraceptive efficacy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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