Product image of Kliogest (Norethisterone Acetate, Estradiol) supplied by GNH India

Kliogest

Active Ingredient:
Norethisterone Acetate, Estradiol
Origin:
EU

Kliogest (Norethisterone Acetate, Estradiol)

Norethisterone acetate and estradiol, the active ingredients in Kliogest, are a combined oral contraceptive presented as an oral tablet for oral use. The formulation combines a progestogenic component with an estrogen component to achieve synergistic suppression of ovulation and stable endometrial changes. They are indicated for reliable contraception and for regulation of menstrual cycles in women of reproductive age.

GNH India supplies Kliogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory conformity across multiple markets.

Manufacturer / TM Owner

Novo Nordisk B.V.

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Indications & Clinical Uses

Kliogest, a combined oral contraceptive, acts on the hypothalamic‑pituitary‑ovarian axis to prevent pregnancy and normalize menstrual bleeding patterns.

  • Contraception: provides reliable prevention of pregnancy when taken as prescribed.
  • Menstrual cycle regulation: helps achieve more predictable and lighter menstrual bleeding.
  • Management of menstrual‑related symptoms: reduces dysmenorrhea and premenstrual mood swings.

How It Works

  • Kliogest contains norethisterone acetate, a synthetic progestogen, and estradiol, a natural estrogen. The progestogen suppresses the mid‑cycle surge of luteinizing hormone, inhibiting ovulation, while the estrogen stabilizes the endometrium and enhances cervical mucus viscosity. Together they create an environment unfavorable for fertilization and implantation, providing contraceptive efficacy and menstrual cycle control.

Side Effects

Kliogest may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset often occurring early in treatment.
  • Breast tenderness: temporary discomfort or swelling of the breasts.
  • Headache: mild to moderate head pain.
  • Spotting or breakthrough bleeding: irregular light bleeding between periods.
  • Weight gain: slight increase in body weight.
  • Mood changes: irritability or emotional fluctuations.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Arterial thrombosis: clot formation in arteries leading to stroke or heart attack.
  • Hypertension: significant increase in blood pressure.
  • Liver dysfunction: abnormal liver enzyme elevations or jaundice.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Visual disturbances: sudden vision loss or blurred vision.

Precautions & Warnings

Before prescribing Kliogest, clinicians should evaluate several safety considerations.

  • Cardiovascular risk assessment: review history of thrombosis, hypertension, or smoking.
  • Liver function evaluation: avoid use in patients with active liver disease.
  • Smoking status: contraindicated in women over 35 who smoke.
  • Pregnancy testing: confirm non‑pregnant status prior to initiation.
  • Drug interaction review: assess concurrent use of enzyme‑inducing medications.
  • Store at ambient temperature: keep tablets below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Kliogest can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Rifampin and other strong CYP3A4 inducers: markedly reduce contraceptive efficacy.
  • St. John’s wort: herbal inducer that may decrease hormone levels.
  • Anticonvulsants such as carbamazepine or phenytoin: lower plasma concentrations of the active hormones.

Moderate Interactions (Monitor Closely)

  • Ketoconazole and other azole antifungals: may increase hormone levels and risk of side effects.
  • Efavirenz (antiretroviral): can modestly reduce contraceptive effectiveness.
  • NSAIDs: may increase risk of gastrointestinal bleeding when combined with estrogen.
  • Diuretics: may exacerbate blood pressure changes.

Frequently Asked Questions

Kliogest is a combined oral contraceptive that is prescribed to prevent pregnancy and to help regulate menstrual cycles. It is used by women of reproductive age who need reliable birth control and more predictable bleeding patterns.

Norethisterone acetate is a synthetic progestogen that suppresses the luteinizing hormone surge, preventing ovulation. Estradiol is an estrogen that stabilizes the endometrium and thickens cervical mucus. Together they create conditions that inhibit fertilization and implantation.

The dosing regimen for Kliogest is determined by the prescribing healthcare professional. It is typically taken as a daily oral tablet according to the specific schedule indicated on the prescription label.

Kliogest is intended for use in non‑pregnant women. If pregnancy occurs, the product should be discontinued and a healthcare provider consulted. Safety during breastfeeding has not been established, so the prescriber will evaluate the risk‑benefit ratio.

To order Kliogest, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kliogest contains norethisterone acetate and estradiol, offering a specific balance of progestogenic and estrogenic activity. Compared with formulations that use ethinyl estradiol, the estradiol component may provide a more physiological estrogen profile, but individual response and side‑effect profiles vary.

Kliogest tablets should be stored at ambient temperature, below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and keep out of reach of children.

Kliogest is taken orally, usually once daily at the same time each day. The tablet is swallowed whole with water and should be taken as directed by the prescriber, following the complete pack cycle.

Serious risks include venous or arterial thrombosis, which can lead to deep‑vein clot, pulmonary embolism, stroke or heart attack. Other critical concerns are severe hypertension, liver dysfunction and rare allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as chest pain, shortness of breath, severe headache or visual changes.

Kliogest should not be used by women who are pregnant, have a known clotting disorder, uncontrolled hypertension, active liver disease, or who are smokers over the age of 35. It is also contraindicated in individuals with a history of estrogen‑dependent tumors or unexplained vaginal bleeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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