Product image of Kliogest (Norethisterone Acetate, Estradiol) supplied by GNH India

Kliogest

Active Ingredient:
Norethisterone Acetate, Estradiol
Origin:
EU

Kliogest (Norethisterone Acetate, Estradiol)

Norethisterone acetate and Estradiol, the active ingredients in Kliogest, are a combined oral contraceptive presented as a tablet for oral use. The formulation prevents ovulation and modifies cervical mucus and endometrial lining to provide reliable contraception and to help regulate menstrual cycles in women of reproductive age.

GNH India supplies Kliogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality assurance, regulatory compliance and reliable global distribution for this product.

Manufacturer / TM Owner

Isdin Laboratorio Farmaceutico Unipessoal Lda.

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Indications & Clinical Uses

  • Kliogest, a combined hormonal contraceptive, acts on the hypothalamic‑pituitary‑ovarian axis to prevent pregnancy and to stabilize menstrual bleeding.
  • Contraception: provides reliable prevention of pregnancy by inhibiting ovulation.
  • Menstrual cycle regulation: helps achieve more predictable cycle length and flow.
  • Management of menstrual disorders: reduces heavy or irregular bleeding associated with hormonal imbalance.

How It Works

  • Kliogest contains norethisterone acetate, a synthetic progestogen, and estradiol, a natural estrogen. The progestogen suppresses the mid‑cycle surge of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH), thereby preventing ovulation. Estradiol stabilizes the endometrium and supports the progestogenic effect, while both agents alter cervical mucus to a less permeable state, reducing sperm penetration. The combined action maintains a hormonal environment that precludes fertilization and implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional tension‑type headache.
  • Breakthrough bleeding: spotting between periods.
  • Weight gain: slight increase in body weight.
  • Mood changes: irritability or mood swings.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Arterial thrombosis: clot formation in arteries.
  • Severe hypertension: markedly elevated blood pressure.
  • Hepatic adenoma: benign liver tumor.
  • Allergic reaction: rash, itching, swelling.
  • Visual disturbances: blurred vision or eye pain.

Precautions & Warnings

  • Kliogest should be used with caution in the following situations.
  • Contraindicated in pregnancy: product is Category X and must not be used.
  • Smoking over age 35: avoid due to increased cardiovascular risk.
  • History of thromboembolism: contraindicated because of clot risk.
  • Liver disease: use with caution; monitor liver function.
  • Hypertension: monitor blood pressure regularly.
  • Store at room temperature below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Kliogest may interact with other medicines; consider the following.

Major Interactions (Avoid)

  • Strong enzyme inducers (e.g., rifampin, carbamazepine): may reduce contraceptive efficacy.
  • Anticoagulants (e.g., warfarin): increased risk of thrombosis.
  • Certain SSRIs (e.g., sertraline): may heighten bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antifungals (e.g., ketoconazole): may raise hormone levels.
  • Some antibiotics (e.g., tetracycline): minimal effect but monitor cycle control.
  • Herbal supplements (e.g., St. John's wort): may lower effectiveness of the contraceptive.

Frequently Asked Questions

Kliogest is a combined hormonal oral tablet that is prescribed to prevent pregnancy and to help regulate menstrual cycles in women of reproductive age. It works by inhibiting ovulation and modifying cervical mucus and the endometrial lining.

Norethisterone acetate is a synthetic progestogen that suppresses the mid‑cycle surge of luteinizing hormone and follicle‑stimulating hormone, preventing ovulation. Estradiol, a natural estrogen, stabilises the endometrium and supports the progestogenic effect while both agents make cervical mucus less permeable to sperm.

The specific dosing regimen for Kliogest is determined by the prescribing healthcare professional based on individual patient needs and local regulatory guidelines. Patients should follow the prescriber’s instructions and the product label.

Kliogest is classified as Pregnancy Category X, meaning it must not be used during pregnancy because it can cause harm to the fetus. It is also not recommended while breastfeeding, as hormonal exposure may affect milk production and infant health.

To order Kliogest, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kliogest contains norethisterone acetate and estradiol, a formulation that offers both progestogenic and estrogenic activity similar to many other combined oral contraceptives. Its efficacy, safety profile and side‑effect spectrum are comparable to other products that use synthetic progestins and natural estrogen, but individual tolerability may vary.

Kliogest tablets should be stored at room temperature below 25 °C, in the original blister pack or container, protected from moisture, heat and direct sunlight. Do not store in the bathroom or near a kitchen sink.

Kliogest is taken orally, usually once daily at the same time each day, as directed by the prescriber. The tablets are swallowed whole with water and should be taken with or without food according to the label instructions.

The most serious risks include venous or arterial thromboembolism, severe hypertension, hepatic adenoma and allergic reactions. Women with a history of clotting disorders, smoking over age 35, or uncontrolled hypertension should avoid using Kliogest.

Kliogest should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or who are smokers over the age of 35. It is also contraindicated in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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