Product image of Kliogest (Norethisterone Acetate, Estradiol) supplied by GNH India

Kliogest

Active Ingredient:
Norethisterone Acetate, Estradiol
Origin:
EU

Kliogest (Norethisterone Acetate, Estradiol)

Norethisterone Acetate and Estradiol, the active ingredients in Kliogest, are a combined oral contraceptive presented as a tablet for oral use. It is used to prevent pregnancy, manage menstrual disorders, and provide hormone replacement therapy for menopausal women.

GNH India supplies Kliogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Kliogest, a combined estrogen‑progestogen oral contraceptive, is indicated for several hormone‑related conditions.

  • Prevention of pregnancy: provides reliable contraception for women of reproductive age.
  • Management of menstrual disorders: reduces irregular bleeding and alleviates dysmenorrhea.
  • Hormone replacement therapy: supplies estrogen and progestogen to relieve menopausal symptoms.

How It Works

  • Norethisterone acetate binds to progesterone receptors, suppressing the hypothalamic‑pituitary‑gonadal axis and preventing the LH surge that triggers ovulation. Estradiol activates estrogen receptors, providing negative feedback to the pituitary and stabilising the endometrium. Together they alter cervical mucus, inhibit follicular development, and create an endometrial environment unsuitable for implantation.

Side Effects

Kliogest may cause a range of adverse reactions. The most frequently reported events are generally mild and transient.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Spotting or breakthrough bleeding
  • Weight change
  • Mood swings

Serious or Rare Side Effects

  • Venous thromboembolism (deep‑vein thrombosis, pulmonary embolism)
  • Stroke or transient ischemic attack
  • Myocardial infarction
  • Severe hypertension
  • Liver dysfunction or cholestasis
  • Allergic reactions, including anaphylaxis

Precautions & Warnings

Before prescribing Kliogest, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Cardiovascular assessment: screen for hypertension, smoking, or a history of thromboembolic disease.
  • Age and smoking: avoid use in women over 35 who smoke.
  • Liver function: monitor patients with hepatic impairment.
  • Blood pressure monitoring: check regularly during therapy.
  • Patient education: advise on signs of VTE, stroke, or severe headache.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kliogest can interact with several medicines, altering its effectiveness or increasing risk of adverse events.

Major Interactions (Avoid)

  • Rifampin and other strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, St. John’s wort) – may reduce contraceptive efficacy.
  • Certain antifungal agents (e.g., ketoconazole) – can increase hormone levels and risk of toxicity.
  • Griseofulvin – may diminish contraceptive protection.

Moderate Interactions (Monitor Closely)

  • Anticoagulants such as warfarin – may require INR monitoring.
  • Antidepressants (SSRIs, SNRIs) – potential for increased mood‑related side effects.
  • Antihypertensive drugs – may experience altered blood pressure control.
  • Anticonvulsants like valproate – may affect hormone metabolism.
  • Herbal supplements (e.g., ginseng) – possible impact on hormone levels.

Frequently Asked Questions

Kliogest is a combined estrogen‑progestogen tablet indicated for preventing pregnancy, managing menstrual irregularities, and providing hormone replacement therapy to alleviate menopausal symptoms in women.

Norethisterone acetate acts as a progestogen, suppressing the hypothalamic‑pituitary‑gonadal axis and preventing ovulation. Estradiol provides estrogenic activity, stabilising the endometrium and contributing to negative feedback on the pituitary, together creating an environment unsuitable for fertilisation and implantation.

The specific dosing regimen for Kliogest is determined by the prescribing clinician based on the patient’s medical history, indication, and local guidelines. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Kliogest is contraindicated during pregnancy because it is intended to prevent conception. Its safety during breastfeeding has not been established; therefore, healthcare providers usually advise against use while nursing unless the benefits outweigh potential risks.

To order Kliogest, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kliogest contains Norethisterone acetate and Estradiol, offering a specific estrogen‑to‑progestogen ratio that may differ from other products using ethinyl‑estradiol or levonorgestrel. The choice depends on individual risk profiles, tolerability, and clinician preference, as each formulation has distinct pharmacokinetic and side‑effect characteristics.

Kliogest tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Kliogest is taken orally, usually once daily at the same time each day, as directed by the prescriber. The tablet should be swallowed whole with water and not chewed or broken.

The most serious risks include venous thromboembolism, stroke, myocardial infarction, severe hypertension, and liver dysfunction. Patients should be educated to seek immediate medical attention if they experience symptoms such as unexplained leg pain, sudden severe headache, chest pain, or visual changes.

Kliogest is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, and in smokers over 35 years of age. It should also be avoided during pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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