Product image of Klion (Metronidazole) supplied by GNH India

Klion

Active Ingredient:
Metronidazole
Origin:
EU

Klion (Metronidazole)

Metronidazole, the active ingredient in Klion, is a nitroimidazole antibiotic presented as a vaginal formulation for local use. It is employed to treat bacterial vaginosis and trichomoniasis in women, targeting anaerobic microorganisms that cause these infections and alleviate symptoms through direct application in the vaginal canal.

GNH India supplies Klion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities for bulk manufacturing, quality assurance, and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Pharmamagist Ltd.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and protozoa in the vaginal tract.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic bacteria.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving discharge and irritation.
  • Anaerobic bacterial vaginitis: reduces pathogenic anaerobes and improves symptoms.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by intracellular electron transport proteins, generating reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and lead to cell death, thereby eliminating the infecting bacteria and protozoa.

Side Effects

Metronidazole may cause local and systemic adverse reactions.

Common Side Effects

  • Vaginal irritation: mild burning or itching at the site of application.
  • Abnormal discharge: temporary change in color or consistency.
  • Odor: unpleasant smell from the vaginal area.
  • Burning sensation: during or after insertion.
  • Dryness: reduced vaginal moisture.
  • Mild headache: occasional transient headache.

Serious or Rare Side Effects

  • Allergic reaction: rash, hives, or swelling requiring medical attention.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: signs of liver injury such as jaundice.
  • Neurological effects: seizures or peripheral neuropathy.
  • Severe gastrointestinal upset: persistent vomiting or abdominal pain.
  • Hematologic changes: unexplained bruising or bleeding.

Precautions & Warnings

Before using Klion, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Allergy: avoid if known hypersensitivity to metronidazole or nitroimidazoles.
  • Alcohol consumption: refrain from alcohol to prevent a disulfiram‑like reaction.
  • Concurrent vaginal products: avoid using other intravaginal medications simultaneously.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines; monitor accordingly.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and vomiting.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma levels.
  • Phenobarbital: may reduce metronidazole effectiveness.
  • Oral contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Klion contains metronidazole and is indicated for the treatment of bacterial vaginosis and trichomoniasis. It works locally in the vagina to eliminate the anaerobic bacteria and protozoa that cause these infections, helping to restore normal vaginal flora and relieve symptoms.

Metronidazole is reduced inside anaerobic microorganisms, producing reactive nitro radicals that damage DNA and other critical biomolecules. This disruption of nucleic acid synthesis leads to cell death, effectively clearing the infection caused by susceptible bacteria and protozoa.

The dosage of Klion is determined by the prescribing healthcare professional based on the specific infection, severity, and patient characteristics. Only a qualified prescriber should set the dose and duration of therapy.

Safety in pregnancy and lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Klion.

To order Klion, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klion (metronidazole) belongs to the nitroimidazole class, which is generally considered first‑line for bacterial vaginosis and trichomoniasis. Alternatives such as tinidazole have similar efficacy but may differ in dosing frequency or side‑effect profile. Choice of therapy depends on clinical judgment, patient tolerance and local resistance patterns.

Klion should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and effectiveness.

Klion is a vaginal formulation intended for local application. The prescribed dose is inserted into the vagina using the supplied applicator or as directed by the healthcare professional, typically once daily for the duration prescribed.

Serious adverse reactions can include severe allergic responses such as rash, hives, or swelling, as well as rare but critical conditions like Stevens‑Johnson syndrome, liver toxicity, seizures, and significant gastrointestinal upset. Patients should seek immediate medical attention if any of these symptoms occur.

Klion should not be used by individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe liver disease, those taking interacting medications such as warfarin or lithium, and anyone who is pregnant or breastfeeding without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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