Product image of Kliqqo (Amlodipine Besilate, Nebivolol Hydrochloride) supplied by GNH India

Kliqqo

Active Ingredient:
Amlodipine Besilate, Nebivolol Hydrochloride
Origin:
EU

Kliqqo (Amlodipine Besilate, Nebivolol Hydrochloride)

Amlodipine besilate and nebivolol hydrochloride, the active ingredients in Kliqqo, are a calcium channel blocker and a beta blocker respectively, presented as an oral tablet for oral use. They lower blood pressure in adults with hypertension.

GNH India supplies Kliqqo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Kliqqo is an antihypertensive medication that acts on vascular tone and cardiac output to control high blood pressure.
  • Essential hypertension: reduces systolic and diastolic blood pressure.
  • Secondary hypertension: assists in controlling pressure when caused by other conditions.
  • Isolated systolic hypertension in the elderly: improves vascular compliance and lowers pressure.

How It Works

  • Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing vasodilation and decreased peripheral resistance. Nebivolol hydrochloride selectively antagonises β1‑adrenergic receptors and enhances nitric‑oxide mediated endothelial relaxation, together producing a synergistic reduction in arterial pressure.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Peripheral edema: swelling of ankles or feet due to fluid accumulation.
  • Dizziness or light‑headedness: related to blood‑pressure lowering.
  • Flushing: transient warmth and redness of the skin.
  • Fatigue: general feeling of tiredness.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure requiring medical attention.
  • Bradycardia: abnormally slow heart rate.
  • Heart block or atrioventricular conduction disturbances.
  • Angioedema: swelling of face, lips, tongue or throat.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider the following precautions.
  • Monitor blood pressure: adjust dosage based on response.
  • Assess renal function: dose may need modification in renal impairment.
  • Evaluate for heart failure: avoid rapid dose escalation in decompensated states.
  • Avoid concomitant strong CYP3A4 inhibitors: may increase nebivolol levels.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Kliqqo may interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with other antihypertensives: risk of excessive hypotension.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase nebivolol exposure.
  • Non‑dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem): additive cardiac depression.

Moderate Interactions (Monitor Closely)

  • Diuretics: may cause electrolyte shifts and augment blood‑pressure lowering.
  • NSAIDs: can attenuate antihypertensive effect.
  • Alcohol: may increase dizziness and hypotension.

Frequently Asked Questions

Kliqqo contains amlodipine besilate and nebivolol hydrochloride and is indicated for the treatment of hypertension in adults. The combination helps lower elevated blood pressure by relaxing blood vessels and reducing heart rate.

Amlodipine besilate is a dihydropyridine calcium‑channel blocker that inhibits calcium entry into vascular smooth‑muscle cells. This inhibition leads to vasodilation, decreased peripheral resistance, and ultimately lower blood pressure.

The prescribed dose of Kliqqo is determined by the treating physician based on the individual’s blood‑pressure response and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Kliqqo during pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk, and a healthcare professional should evaluate each case.

Submit an enquiry on the product page at gnhindia.com, providing the required quantity and institutional credentials. GNH India will verify eligibility and reply with pricing, availability, shipping terms and any necessary import documentation.

Kliqqo combines a calcium‑channel blocker and a beta‑blocker, offering complementary mechanisms that may achieve better blood‑pressure control than monotherapy. Other classes such as ACE inhibitors or ARBs act via the renin‑angiotensin system, providing alternative pathways.

Kliqqo tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the medication out of reach of children.

Kliqqo is taken orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water; do not chew, crush, or split the tablet unless instructed by a healthcare professional.

Patients should be alert for signs of severe hypotension, bradycardia, syncope, angioedema, or liver dysfunction. Any of these symptoms require immediate medical evaluation.

Kliqqo is contraindicated in individuals with known hypersensitivity to amlodipine, nebivolol, or any excipients, and should be avoided in patients with severe aortic stenosis, cardiogenic shock, or uncontrolled heart failure unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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