Product image of Kllotas (Dutasteride, Tamsulosin Chloride) supplied by GNH India

Kllotas

Active Ingredient:
Dutasteride, Tamsulosin Chloride
Origin:
EU

Kllotas (Dutasteride, Tamsulosin Chloride)

Dutasteride/Tamsulosin, the active ingredients in Kllotas, are a 5-alpha-reductase inhibitor and an alpha-1 adrenergic blocker presented as an oral tablet for oral use. The combination is indicated for the treatment of benign prostatic hyperplasia in adult men, helping to improve urinary flow and reduce prostate size.

GNH India supplies Kllotas as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch. Global logistics are coordinated to ensure timely delivery across diverse markets.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

  • Kllotas acts on the hormonal and smooth-muscle pathways that contribute to benign prostatic hyperplasia.
  • Benign prostatic hyperplasia (BPH): reduces prostate volume and alleviates urinary symptoms such as frequency and urgency.
  • Lower urinary tract symptoms (LUTS) due to BPH: improves urinary flow rate and decreases nocturia.
  • Prostate enlargement in adult men: helps to prevent disease progression and the need for surgical intervention.

How It Works

  • Dutasteride inhibits both type I and type II 5-alpha-reductase enzymes, decreasing the conversion of testosterone to dihydrotestosterone and thereby lowering intraprostatic DHT levels. Tamsulosin selectively antagonizes α1A‑adrenergic receptors in the prostate and bladder neck, causing smooth‑muscle relaxation. The combined effect reduces prostate size and eases urinary outflow, addressing both hormonal growth and dynamic obstruction. By targeting these distinct pathways, the formulation provides a synergistic approach to managing BPH.

Side Effects

Kllotas may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Erectile dysfunction: reduced ability to achieve or maintain an erection.
  • Decreased libido: lowered sexual desire.
  • Dizziness: sensation of light‑headedness, especially after standing.
  • Ejaculatory disorder: reduced volume or painful ejaculation.

Serious or Rare Side Effects

  • Orthostatic hypotension: marked drop in blood pressure upon standing, leading to fainting.
  • Priapism: prolonged, painful erection requiring emergency care.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Monitor prostate-specific antigen (PSA) levels: Dutasteride can lower PSA, potentially masking cancer detection.
  • Assess cardiovascular status: Tamsulosin may cause hypotension; caution in patients with heart disease.
  • Avoid use in women of childbearing potential: drug may cause fetal harm.
  • Review concomitant medications: potential interactions with CYP3A4 inhibitors.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Kllotas can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase dutasteride exposure.
  • Alpha‑blocker combinations (e.g., doxazosin, terazosin): risk of additive hypotension.
  • Warfarin: tamsulosin may enhance anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): tamsulosin may affect metabolism.
  • Antihypertensive agents (e.g., ACE inhibitors): may require dose adjustment.
  • Rifampin: may reduce dutasteride levels.

Frequently Asked Questions

Kllotas is a prescription oral tablet that combines dutasteride and tamsulosin to treat benign prostatic hyperplasia (BPH) in adult men. The medication works to shrink the prostate and relax smooth muscle in the prostate and bladder neck, thereby improving urinary flow and reducing symptoms such as frequent urination and urgency.

Dutasteride blocks both type I and type II 5‑alpha‑reductase enzymes, lowering the conversion of testosterone to dihydrotestosterone, which reduces prostate growth. Tamsulosin selectively antagonizes α1A‑adrenergic receptors in the prostate and bladder neck, causing smooth‑muscle relaxation. Together they address hormonal enlargement and dynamic obstruction that cause BPH symptoms.

The dosage of Kllotas is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and concomitant therapies. Physicians typically follow established guidelines for dutasteride and tamsulosin, but the exact strength and frequency should only be set by a qualified healthcare professional.

Kllotas is not indicated for use in women, including those who are pregnant or breastfeeding. Dutasteride can affect fetal development, and tamsulosin has not been studied in these populations. Women of child‑bearing potential should avoid handling the medication and should discuss any exposure concerns with a healthcare provider.

To order Kllotas, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements if applicable) and the necessary import documentation.

Kllotas combines two mechanisms—hormonal suppression (dutasteride) and smooth‑muscle relaxation (tamsulosin)—offering a broader therapeutic effect than monotherapy with either agent alone. Compared with finasteride, dutasteride provides more complete 5‑alpha‑reductase inhibition. Compared with tamsulosin alone, the combination also reduces prostate size, potentially decreasing the need for surgical intervention.

Kllotas tablets should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Kllotas is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water. Patients should follow any specific instructions regarding timing relative to other medications to minimize interaction risk.

Serious adverse events include orthostatic hypotension, which can cause fainting; priapism, a prolonged painful erection requiring emergency care; and severe allergic reactions such as rash, swelling or breathing difficulty. Patients should seek immediate medical attention if any of these symptoms occur.

Kllotas should not be used by women, children, or anyone with a known hypersensitivity to dutasteride, tamsulosin, or any tablet excipients. Patients with severe liver impairment, uncontrolled hypotension, or a history of priapism should also avoid this medication unless a physician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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