Product image of Klomipramin Mylan (Clomipramine) supplied by GNH India

Klomipramin Mylan

Active Ingredient:
Clomipramine
Origin:
EU

Klomipramin Mylan (Clomipramine)

Clomipramine, the active ingredient in Klomipramin Mylan, is a tricyclic antidepressant presented as an oral dosage form for oral use. It is used to treat major depressive disorder and obsessive‑compulsive disorder in adults.

GNH India supplies Klomipramin Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Ab

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Indications & Clinical Uses

Clomipramine is indicated for conditions within the depressive and obsessive‑compulsive disorder spectrum.

  • Major depressive disorder: alleviates depressive symptoms and improves mood.
  • Obsessive‑compulsive disorder: reduces compulsive thoughts and repetitive behaviors.
  • Depressive symptoms in other psychiatric conditions: provides relief of depressive features.

How It Works

  • Clomipramine inhibits the reuptake of serotonin and norepinephrine at neuronal synapses, increasing their extracellular concentrations. This dual neurotransmitter elevation enhances mood regulation and reduces obsessive thoughts by modulating central monoaminergic pathways. The drug also exhibits weak antagonism at muscarinic, histamine H1, and alpha‑adrenergic receptors, contributing to its overall pharmacological profile.

Side Effects

Clomipramine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dry mouth: reduced salivary secretion leading to discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Drowsiness or fatigue: central nervous system sedation.
  • Weight gain: increased appetite and metabolic changes.
  • Blurred vision: transient visual disturbances.
  • Dizziness: light‑headedness, especially on standing.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potential conduction abnormalities.
  • Seizures: lowered seizure threshold.
  • Severe hypotension: marked drop in blood pressure.
  • Agranulocytosis: dangerous reduction in white blood cells.
  • Suicidal thoughts: emergence of suicidal ideation.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.

Precautions & Warnings

When prescribing clomipramine, clinicians should consider several safety measures.

  • Monitor cardiac function: obtain baseline ECG and repeat as needed due to arrhythmia risk.
  • Assess for suicidal ideation: especially during treatment initiation and dose changes.
  • Avoid abrupt discontinuation: taper gradually under medical supervision to prevent withdrawal.
  • Use caution in glaucoma patients: anticholinergic effects may exacerbate intra‑ocular pressure.
  • Avoid concomitant MAO inhibitors: risk of serotonin syndrome.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Clomipramine interacts with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: may precipitate serotonin syndrome.
  • SSRIs and SNRIs: increase risk of serotonin toxicity.
  • Other tricyclic antidepressants: additive cardiotoxic effects.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine): raise clomipramine plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may intensify dry mouth and constipation.
  • Beta‑blockers: can enhance bradycardia.
  • Diuretics: may potentiate hypotensive effects.

Frequently Asked Questions

Klomipramin Mylan, containing clomipramine, is prescribed for major depressive disorder and obsessive‑compulsive disorder in adult patients. It helps alleviate depressive symptoms and reduces compulsive thoughts and behaviors associated with these conditions.

Clomipramine works by blocking the reuptake of serotonin and norepinephrine, increasing their levels in the brain. This dual action enhances mood regulation and diminishes obsessive thoughts, while also providing mild antagonism at certain receptor sites that contributes to its overall effect.

The appropriate dose of Klomipramin Mylan is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage adjustments are made according to clinical judgment and patient-specific factors.

Safety data for clomipramine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clomipramine belongs to the tricyclic antidepressant class, offering a dual serotonin‑norepinephrine reuptake inhibition that differs from selective serotonin reuptake inhibitors (SSRIs). It may be more effective for obsessive‑compulsive disorder but typically has a higher side‑effect burden compared with newer agents.

Klomipramin Mylan should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and potency.

Klomipramin Mylan is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule, including timing and any dose titration, is determined by the treating physician.

Serious risks include cardiac arrhythmias, seizures, severe hypotension, agranulocytosis, emergence of suicidal thoughts, and rare but severe allergic reactions. Patients should be monitored closely for these events, especially during treatment initiation or dose changes.

Klomipramin Mylan is contraindicated in patients with known hypersensitivity to clomipramine or other tricyclic antidepressants, those currently taking monoamine oxidase inhibitors, and individuals with certain cardiac conditions that predispose them to arrhythmias. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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