Product image of Klont (Metronidazole) supplied by GNH India

Klont

Active Ingredient:
Metronidazole
Origin:
EU

Klont (Metronidazole)

Metronidazole, the active ingredient in Klont, is a Nitroimidazole antibiotic presented as an oral tablet for oral use. It treats bacterial and protozoal infections in adults and adolescents.

GNH India supplies Klont as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: eliminates the anaerobic bacteria that cause the condition, relieving discharge and odor.
  • Trichomoniasis: eradicates Trichomonas vaginalis, curing the infection and preventing recurrence.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic and skin infections.
  • Giardiasis: clears Giardia lamblia from the gastrointestinal tract, relieving diarrhea and abdominal cramps.

How It Works

  • Metronidazole is reduced inside anaerobic microorganisms to reactive nitro radicals that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis. This damage leads to loss of cell viability and bacterial or protozoal death, while aerobic cells remain largely unaffected.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing head pain.
  • Abdominal discomfort: cramping or mild pain in the abdomen.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring urgent care.

Precautions & Warnings

Metronidazole should be used with caution in specific clinical situations.

  • Pregnancy (Category B): prescribe only when benefits outweigh potential risks.
  • Alcohol consumption: avoid alcohol to prevent a disulfiram‑like reaction.
  • Liver disease: monitor hepatic function and adjust therapy if needed.
  • Renal impairment: assess kidney function and consider dose modification.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea and tachycardia.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduces metronidazole concentrations, possibly decreasing effectiveness.
  • Cimetidine: can increase metronidazole plasma levels.
  • Carbamazepine: may lower metronidazole levels, requiring therapeutic monitoring.

Frequently Asked Questions

Klont, containing metronidazole, is prescribed for infections such as bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis and a variety of anaerobic bacterial infections. It targets organisms that thrive in low‑oxygen environments, helping to clear the infection and relieve associated symptoms.

Metronidazole enters anaerobic bacteria and protozoa and is reduced to reactive nitro radicals. These radicals bind to DNA, causing strand breaks and inhibiting nucleic acid synthesis, which ultimately leads to cell death while sparing most aerobic cells.

The specific dose of Klont is determined by the prescribing clinician based on the infection being treated, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Metronidazole is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy only if the potential benefit justifies the risk. Caution is advised while breastfeeding; a healthcare provider should evaluate the situation.

To request Klont, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with alternatives such as tinidazole, metronidazole (Klont) has a similar spectrum against anaerobic bacteria and protozoa but differs in half‑life and dosing frequency. Metronidazole is often chosen for its extensive clinical experience, lower cost, and established safety profile, while tinidazole may require fewer doses for some infections.

Klont should be stored below 25 °C in a dry place, kept in its original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Klont is taken orally, usually with food or a full glass of water to reduce gastrointestinal irritation. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include seizures, peripheral neuropathy, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience neurological symptoms, rash, swelling, or difficulty breathing.

Klont is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. It should also be avoided in patients with severe hepatic impairment unless benefits outweigh risks, and in those who are currently consuming alcohol.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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