Product image of Klont (Metronidazole) supplied by GNH India

Klont

Active Ingredient:
Metronidazole
Origin:
EU

Klont (Metronidazole)

Metronidazole, the active ingredient in Klont, is a nitroimidazole antibiotic presented as an oral dosage form for oral use. It treats infections caused by anaerobic bacteria and certain protozoa in adults and pediatric patients as prescribed by a healthcare professional, and is indicated for a range of anaerobic bacterial and protozoal infections.

GNH India supplies Klont as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, quality assurance and regulatory support for global healthcare providers.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Metronidazole acts on anaerobic bacteria and protozoa, providing antimicrobial therapy for several infections.

  • Bacterial vaginosis: eradicates anaerobic bacterial overgrowth in the vaginal flora.
  • Trichomoniasis: eliminates the protozoan parasite Trichomonas vaginalis.
  • Anaerobic bacterial infections: treats intra‑abdominal, pelvic and soft‑tissue infections caused by anaerobes.
  • Amoebiasis: clears intestinal infection by Entamoeba histolytica.
  • Clostridioides difficile infection: reduces toxin‑producing bacterial load in the colon.

How It Works

  • Metronidazole penetrates anaerobic microorganisms and is reduced by intracellular electron transport proteins, generating reactive nitro radicals. These radicals interact with DNA, causing strand breakage and loss of helical structure, which inhibits nucleic acid synthesis and leads to cell death of susceptible bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient alteration of taste perception.
  • Diarrhea: loose stools, sometimes watery.
  • Abdominal pain: cramping or discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.
  • Hepatotoxicity: liver enzyme elevation or injury.
  • Blood dyscrasias: neutropenia, thrombocytopenia, or aplastic anemia.

Precautions & Warnings

When using Metronidazole, consider the following safety measures.

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Avoid alcohol: risk of disulfiram‑like reaction with flushing and vomiting.
  • Use with caution in pregnancy: consult obstetric care for risk‑benefit assessment.
  • Monitor for signs of superinfection: secondary bacterial overgrowth may occur.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Metronidazole can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause severe nausea, vomiting, and flushing.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: can increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole efficacy by inducing metabolism.
  • Oral contraceptives: may reduce hormonal effectiveness, requiring additional contraception.

Frequently Asked Questions

Klont (Metronidazole) is prescribed for infections caused by anaerobic bacteria and certain protozoa, including bacterial vaginosis, trichomoniasis, intra‑abdominal anaerobic infections, amoebiasis, and Clostridioides difficile infection, as determined by a qualified healthcare professional.

Metronidazole enters anaerobic microorganisms and is reduced by their electron transport proteins, producing reactive nitro radicals. These radicals damage DNA, disrupting nucleic acid synthesis and leading to cell death of susceptible bacteria and protozoa.

The dosage of Klont (Metronidazole) is individualized by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety of Metronidazole in pregnancy or lactation should be evaluated by a healthcare provider. The drug may be used when the potential benefit outweighs any risk, but a prescriber will consider the trimester and alternative therapies before recommending use.

To order Klont, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klont (Metronidazole) shares the same class mechanism as other nitroimidazoles, offering broad activity against anaerobic bacteria and protozoa. Compared with alternatives, it is widely used due to its established efficacy, oral formulation, and extensive clinical experience, though choice depends on infection type, resistance patterns and patient factors.

Klont should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Klont is taken orally, usually with a full glass of water. The exact dosing schedule, including frequency and duration, is determined by the prescriber based on the infection being treated and patient-specific considerations.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as Stevens‑Johnson syndrome, hepatotoxicity, and blood dyscrasias like neutropenia or aplastic anemia. Patients should seek immediate medical attention if they experience any of these severe symptoms.

Klont should be avoided in individuals with known hypersensitivity to metronidazole or other nitroimidazoles, in patients with severe hepatic impairment, and in those who are unable to abstain from alcohol during therapy due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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