Product image of Kloramfenikol (Chloramphenicol) supplied by GNH India

Kloramfenikol

Active Ingredient:
Chloramphenicol
Origin:
EU

Kloramfenikol (Chloramphenicol)

Chloramphenicol, the active ingredient in Kloramfenikol, is an amphenicol presented as a topical ophthalmic solution for ocular use. It is indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis and blepharitis in both adult and pediatric patients.

GNH India supplies Kloramfenikol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

Chloramphenicol is an antibacterial agent used in ophthalmology to manage infections of the eye surface and structures.

  • Conjunctivitis: reduces bacterial load and promotes resolution of inflammation.
  • Keratitis: treats bacterial corneal infection and aids healing.
  • Blepharitis: helps control bacterial involvement of the eyelid margins.

How It Works

  • Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. This action halts bacterial growth (bacteriostatic) across a broad spectrum of Gram‑positive and Gram‑negative organisms commonly implicated in ocular infections.

Side Effects

Adverse reactions may occur with ocular chloramphenicol use.

Common Side Effects

  • Mild eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Transient blurred vision.
  • Local itching or discomfort.
  • Mild allergic eyelid edema.
  • Temporary tearing.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling and difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis involving the ocular surface.
  • Bone marrow suppression leading to aplastic anemia (systemic absorption risk).
  • Contact dermatitis around the peri‑ocular area.
  • Persistent corneal ulceration.
  • Vision loss due to severe ocular inflammation.

Precautions & Warnings

When using Kloramfenikol, consider the following safety measures.

  • Allergic History: avoid if known hypersensitivity to chloramphenicol or other amphenicols.
  • Pregnancy: use only if clearly needed; safety data are limited.
  • Breastfeeding: consult a healthcare professional before use.
  • Systemic Absorption: monitor for signs of bone‑marrow suppression, especially with prolonged therapy.
  • Contact Lens Wearers: remove lenses before application and wait before reinserting.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Chloramphenicol may interact with other agents affecting its efficacy or safety.

Major Interactions (Avoid)

  • Systemic aminoglycosides: increased risk of ototoxicity when absorbed.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Other topical antibiotics: may reduce effectiveness if used concurrently.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for additive irritation.
  • Corticosteroid eye drops: increased risk of secondary infection.

Frequently Asked Questions

Kloramfenikol is a topical ophthalmic solution containing chloramphenicol, used to treat bacterial infections of the eye such as conjunctivitis, keratitis and blepharitis. It works by inhibiting bacterial protein synthesis, helping to clear the infection and reduce inflammation.

Chloramphenicol binds to the bacterial 50S ribosomal subunit, blocking peptide bond formation and halting protein synthesis. This bacteriostatic action limits the growth of susceptible Gram‑positive and Gram‑negative organisms that cause ocular infections.

The dosing regimen for Kloramfenikol is determined by the prescribing clinician based on the type and severity of the eye infection, patient age and response to therapy. The prescriber will specify the number of drops, frequency and duration of treatment.

Safety data for chloramphenicol eye drops in pregnancy and lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and discuss with a healthcare professional before starting therapy.

To order Kloramfenikol, submit an enquiry on the product page at gnhindia.com, providing the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then replies with pricing, availability, shipping details and any necessary import documentation.

Compared with other topical antibiotics such as fluoroquinolones, chloramphenicol offers a broad spectrum against both Gram‑positive and Gram‑negative bacteria and is often used where resistance to newer agents is a concern. However, it may have a higher risk of rare systemic side effects, so choice depends on clinical judgment.

Store Kloramfenikol at ambient temperature, below 25 °C, in its original container. Protect the solution from moisture, direct sunlight and extreme temperatures to maintain stability and potency.

Kloramfenikol is applied as eye drops. The prescribed number of drops is placed into the conjunctival sac of the affected eye(s) at the intervals indicated by the prescriber, usually without touching the tip to the eye or surrounding tissues.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare systemic bone‑marrow suppression leading to aplastic anemia. Immediate medical attention is required if any of these symptoms develop.

Patients with a known hypersensitivity to chloramphenicol or other amphenicol antibiotics should avoid Kloramfenikol. Caution is also advised for individuals with a history of bone‑marrow disorders, and it should be used only when clearly needed during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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