Product image of Kloramfenikol Sandoz (Chloramphenicol) supplied by GNH India

Kloramfenikol Sandoz

Active Ingredient:
Chloramphenicol
Origin:
EU

Kloramfenikol Sandoz (Chloramphenicol)

Chloramphenicol, the active ingredient in Kloramfenikol Sandoz, is an amphenicol presented as a topical ophthalmic preparation for ocular use. It treats bacterial conjunctivitis, keratitis and other ocular bacterial infections in patients requiring eye therapy.

GNH India supplies Kloramfenikol Sandoz as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz A/S

1
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Indications & Clinical Uses

Chloramphenicol is an antibacterial agent used to manage ocular bacterial infections.

  • Bacterial conjunctivitis: reduces bacterial load and resolves inflammation of the conjunctiva.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Other ocular bacterial infections: treats infection and helps prevent sight‑threatening complications.

How It Works

  • Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking peptide bond formation. This action prevents bacterial growth and replication, leading to a bacteriostatic effect against a broad range of Gram‑positive and Gram‑negative ocular pathogens.

Side Effects

Adverse reactions may occur following ocular administration of chloramphenicol.

Common Side Effects

  • Eye irritation or burning sensation.
  • Stinging upon instillation.
  • Redness of the conjunctiva.
  • Transient blurred vision.
  • Mild allergic conjunctivitis.
  • Local dryness.

Serious or Rare Side Effects

  • Aplastic anemia (systemic toxicity if absorbed).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe ocular hypersensitivity reactions.
  • Systemic bone‑marrow suppression.
  • Severe dermatitis.
  • Vision‑threatening corneal ulceration secondary to hypersensitivity.

Precautions & Warnings

Use chloramphenicol eye drops only under medical supervision and observe the following precautions.

  • Hypersensitivity: avoid in patients with known allergy to chloramphenicol or other amphenicols.
  • Hematologic disorders: monitor patients with pre‑existing bone‑marrow disease.
  • Duration of therapy: limit use to the prescribed period, typically not exceeding 7 days unless directed.
  • Systemic absorption: be aware of rare systemic effects, especially with extensive ocular surface damage.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Chloramphenicol may interact with other medicines; consider the following.

Major Interactions (Avoid)

  • Systemic chloramphenicol: additive risk of bone‑marrow suppression.
  • Warfarin: increased anticoagulant effect, monitor INR closely.
  • Carbamazepine: enzyme induction may reduce chloramphenicol levels.
  • Oral contraceptives: possible reduction in efficacy.
  • Cyclosporine: enhanced risk of nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase ocular irritation.
  • Other topical ophthalmic antibiotics: potential antagonism or reduced efficacy.
  • Tetracyclines: possible decreased antibacterial activity when co‑administered.

Frequently Asked Questions

Kloramfenikol Sandoz contains chloramphenicol and is indicated for the treatment of bacterial infections of the eye, such as bacterial conjunctivitis, bacterial keratitis, and other ocular bacterial infections. It is applied topically to the affected eye to reduce bacterial load and promote healing.

Chloramphenicol works by binding to the 50S subunit of bacterial ribosomes, inhibiting peptide bond formation and thereby blocking protein synthesis. This bacteriostatic action stops bacterial growth, allowing the immune system to clear the infection from the ocular surface.

The dosing regimen for Kloramfenikol Sandoz is determined by the prescribing clinician based on the type and severity of the ocular infection. The prescriber will specify the number of drops, frequency, and duration of therapy.

Safety of chloramphenicol eye drops during pregnancy or lactation has not been definitively established. Healthcare professionals should weigh the potential benefits against possible risks and consider alternative treatments when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Chloramphenicol offers a broad spectrum of activity against both Gram‑positive and Gram‑negative ocular pathogens and is often used when resistance to fluoroquinolones or macrolides is a concern. Unlike some newer agents, it is bacteriostatic rather than bactericidal, and systemic toxicity is rare with proper ocular use.

Store the product at room temperature, below 25 °C, in the original packaging. Protect it from direct light, moisture and extreme temperatures to maintain stability and potency.

The medication is applied as eye drops. The prescriber will instruct the patient on the correct technique, typically instilling the specified number of drops into the affected eye(s) at the recommended intervals, avoiding contact with the ocular surface to maintain sterility.

Serious risks, though rare, include systemic bone‑marrow suppression such as aplastic anemia, severe allergic reactions like Stevens‑Johnson syndrome, and toxic epidermal necrolysis. Patients should be advised to seek immediate medical attention if they experience unexplained fatigue, bruising, rash, or severe eye pain.

Individuals with a known hypersensitivity to chloramphenicol or other amphenicols should avoid this product. Patients with pre‑existing bone‑marrow disorders, severe ocular surface disease, or those who are pregnant or breastfeeding without professional guidance should also be cautioned.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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