Product image of Kloramfenikol Sandoz (Chloramphenicol) supplied by GNH India

Kloramfenikol Sandoz

Active Ingredient:
Chloramphenicol
Origin:
EU

Kloramfenikol Sandoz (Chloramphenicol)

Chloramphenicol, the active ingredient in Kloramfenikol Sandoz, is a amphenicol antibiotic presented as an ocular preparation for eye use. It is employed to treat bacterial infections of the eye surface and surrounding tissues in patients of all ages.
GNH India supplies Kloramfenikol Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz A/S

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Indications & Clinical Uses

Chloramphenicol is an ophthalmic antibiotic used to manage bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and relieves redness, discharge and irritation.
  • Blepharitis: controls bacterial overgrowth on eyelid margins, decreasing inflammation and crusting.
  • Superficial keratitis: eradicates susceptible organisms to promote corneal healing and prevent ulceration.

How It Works

  • Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking peptide bond formation. This action halts bacterial growth, rendering the organism unable to replicate and allowing the host immune system to clear the infection.

Side Effects

Chloramphenicol eye drops may cause local and systemic adverse reactions.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Temporary blurred vision.
  • Mild eye irritation or itching.
  • Conjunctival hyperemia (redness).
  • Local allergic contact dermatitis.

Serious or Rare Side Effects

  • Aplastic anemia (systemic, rare).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe hypersensitivity reactions including anaphylaxis.
  • Systemic bone‑marrow suppression with prolonged use.
  • Vision loss due to corneal toxicity (very rare).

Precautions & Warnings

Before using Kloramfenikol Sandoz, consider the following precautions.

  • Allergy assessment: avoid if the patient has known hypersensitivity to chloramphenicol or other amphenicols.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant.
  • Systemic absorption: monitor for signs of bone‑marrow suppression, especially with extensive or prolonged therapy.
  • Contact lens wearers: remove lenses before application and wait at least 15 minutes before reinserting.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Chloramphenicol can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Systemic aminoglycosides: may increase ototoxic risk.
  • Warfarin: chloramphenicol can potentiate anticoagulant effect, raising bleeding risk.
  • Phenobarbital or other enzyme inducers: may reduce chloramphenicol plasma levels, decreasing efficacy.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation when used concurrently.
  • Oral contraceptives: chloramphenicol may diminish hormonal contraceptive effectiveness.
  • Alcohol: concurrent use may heighten risk of hepatic toxicity.

Frequently Asked Questions

Kloramfenikol Sandoz is an ophthalmic preparation containing chloramphenicol, used to treat bacterial infections of the eye such as conjunctivitis, blepharitis and superficial keratitis. It works by eliminating susceptible bacteria, helping to reduce inflammation, discharge and discomfort associated with these conditions.

Chloramphenicol interferes with bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. This halts bacterial growth, allowing the body's immune defenses to clear the infection. The action is localized to the ocular surface when administered as eye drops.

The dosing regimen for Kloramfenikol Sandoz is determined by the prescribing clinician based on the type and severity of the eye infection, patient age and response to therapy. The prescriber will specify the number of drops, frequency and duration of treatment.

Chloramphenicol crosses the placenta and may be secreted in breast milk. Use during pregnancy or lactation is only recommended when the potential benefit outweighs the potential risk to the fetus or infant. The prescriber should evaluate the individual situation before prescribing.

To request Kloramfenikol Sandoz, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Chloramphenicol offers broad‑spectrum coverage against many Gram‑positive and some Gram‑negative ocular pathogens and is often used when resistance to fluoroquinolones is a concern. Compared with newer agents, it may have a lower risk of developing resistance but requires careful monitoring for rare systemic toxicity.

Kloramfenikol Sandoz should be stored below 25 °C in its original packaging, protected from moisture and direct light. Do not freeze the product. Ensure the container is tightly closed when not in use to maintain sterility and potency.

The product is applied topically to the affected eye(s) as directed by the prescriber. Typically, a few drops are placed in the conjunctival sac, avoiding contact with the eyelid or lashes. Patients should wash their hands before and after administration and follow any specific instructions regarding contact lens use.

Serious risks, though rare, include aplastic anemia, Stevens‑Johnson syndrome and toxic epidermal necrolysis, which are systemic hypersensitivity reactions. Immediate medical attention is required if patients experience unexplained fatigue, bruising, skin blistering or severe allergic symptoms while using the eye drops.

Patients with a known hypersensitivity to chloramphenicol or other amphenicol antibiotics should avoid this product. It is also contraindicated in individuals with a history of severe bone‑marrow suppression or those who have experienced serious allergic reactions to topical ophthalmic antibiotics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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