Klorhexidinsprit Fresenius Kabi (Chlorhexidine Gluconate)

Chlorhexidine gluconate is an antiseptic that acts on a broad range of bacteria, fungi and viruses on the skin.

• Pre‑operative skin preparation: reduces microbial load on the skin before surgical procedures.
• Wound cleansing: helps prevent infection in minor cuts, abrasions and superficial burns.
• Catheter site care: maintains aseptic condition of peripheral or central catheter insertion sites.
• Hand hygiene in clinical settings: provides rapid, broad‑spectrum antimicrobial action for healthcare workers.
• Skin antisepsis before injections: lowers the risk of local infection at injection sites.
• Skin antisepsis before minor procedures: creates a sterile field for dermatologic or dental interventions.

• Chlorhexidine gluconate exerts its antiseptic effect by binding to bacterial cell membranes, disrupting membrane integrity and causing leakage of intracellular components. This loss of essential ions and metabolites leads to rapid cell death across a wide spectrum of Gram‑positive and Gram‑negative bacteria, as well as certain fungi and enveloped viruses.

Adverse reactions may occur following topical application of chlorhexidine gluconate.

Common Side Effects

• Skin irritation: mild redness or burning at the application site.
• Pruritus: localized itching.
• Mild erythema: slight reddening of the skin.
• Dryness: temporary loss of skin moisture.
• Sensation of tightness: brief feeling of skin tightness after use.

Serious or Rare Side Effects

• Anaphylaxis: severe, life‑threatening allergic reaction.
• Contact dermatitis: intense rash with swelling and blistering.
• Chemical burns: deep tissue injury from prolonged exposure.
• Severe urticaria: widespread hives.
• Systemic toxicity: rare absorption leading to hypotension or arrhythmia.

When using chlorhexidine gluconate, consider the following safety measures.

• Allergy assessment: avoid use in patients with known hypersensitivity to chlorhexidine.
• Open wounds: ensure the product is appropriate for the wound type and depth.
• Eye exposure: do not apply near or in the eyes; rinse immediately if accidental contact occurs.
• Mucous membranes: avoid application to oral, nasal or genital mucosa unless specifically indicated.
• Store at ambient temperature: keep container tightly closed, protect from light and moisture.

Chlorhexidine gluconate can interact with certain agents applied to the skin.

Major Interactions (Avoid)

• Anesthetic agents (e.g., lidocaine): may reduce antiseptic efficacy when applied sequentially.
• Iodine‑containing dressings: can cause chemical incompatibility and diminish antimicrobial activity.

Moderate Interactions (Monitor Closely)

• Alcohol‑based hand rubs: may increase risk of skin irritation when used together.
• Topical antibiotics: monitor for additive irritation or allergic responses.
• Skin moisturizers: may dilute antiseptic effect, requiring careful timing of application.