Product image of Klorzoxazon Evolan (Chlorzoxazone) supplied by GNH India

Klorzoxazon Evolan

Active Ingredient:
Chlorzoxazone
Origin:
EU

Klorzoxazon Evolan (Chlorzoxazone)

Chlorzoxazone, the active ingredient in Klorzoxazon Evolan, is a muscle relaxant presented as an oral tablet for oral use. It is used to relieve muscle spasm and acute musculoskeletal pain in adult patients.
GNH India supplies Klorzoxazon Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Chlorzoxazone is indicated for conditions involving skeletal muscle spasm and acute musculoskeletal pain.

  • Muscle spasm: provides relief of pain and stiffness associated with involuntary muscle contraction.
  • Acute low back pain: helps reduce discomfort during the early phase of low back strain.
  • Post‑operative muscle spasm: aids in controlling spasm after surgical procedures.

How It Works

  • Chlorzoxazone acts centrally by inhibiting polysynaptic reflex pathways in the spinal cord, which reduces the transmission of excitatory signals to skeletal muscles. This attenuation of reflex activity leads to a decrease in muscle tone and spasm without directly affecting the contractile apparatus of the muscle fibers.

Side Effects

Common Side Effects

  • Drowsiness: a feeling of sleepiness or reduced alertness.
  • Dizziness: sensation of light‑headedness or imbalance.
  • Nausea: mild to moderate upset stomach.
  • Headache: transient pain in the head region.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver injury such as jaundice or elevated enzymes.
  • Severe skin reactions: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Blood dyscrasias: such as agranulocytosis or aplastic anemia.
  • Anaphylaxis: acute allergic reaction with breathing difficulty or swelling.

Precautions & Warnings

Chlorzoxazone should be used with caution in specific clinical situations.

  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Liver disease: monitor hepatic function and consider dose adjustment.
  • Elderly: increased sensitivity to central effects; start with the lowest effective dose.
  • Concomitant CNS depressants: may enhance sedation; observe for excessive drowsiness.
  • Alcohol: may increase drowsiness and dizziness; advise avoidance.
  • Store at ambient temperature: keep below 25°C, in the original container, protect from moisture.

Avoid Interactions

Chlorzoxazone may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • CNS depressants (opioids, benzodiazepines, barbiturates): may cause profound sedation.
  • Alcohol: additive CNS depression leading to marked drowsiness.
  • Liver enzyme inducers (rifampin, carbamazepine): may lower plasma concentrations and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Antihistamines: can increase sedation.
  • Tricyclic antidepressants: may enhance central nervous system depression.
  • Anticonvulsants (phenytoin): may alter chlorzoxazone metabolism.

Frequently Asked Questions

Klorzoxazon Evolan contains chlorzoxazone, a centrally acting muscle relaxant prescribed to relieve skeletal muscle spasm and to alleviate acute musculoskeletal pain such as low‑back strain or postoperative muscle tension.

Chlorzoxazone reduces muscle spasm by inhibiting polysynaptic reflexes within the spinal cord. This central action dampens excitatory neural pathways, decreasing the transmission of signals that cause involuntary muscle contraction.

The specific dose of Klorzoxazon Evolan is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Dosage instructions are provided on the prescription label.

Safety data for chlorzoxazone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Chlorzoxazone is a centrally acting skeletal muscle relaxant, similar in effect to drugs like cyclobenzaprine or methocarbamol but differs in its specific mechanism of inhibiting spinal polysynaptic reflexes. Its side‑effect profile and drug‑interaction potential may vary, making it a suitable alternative for patients who cannot tolerate other agents.

Klorzoxazon Evolan tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any dietary considerations.

Serious adverse reactions, though rare, include liver toxicity, severe skin reactions such as Stevens‑Johnson syndrome, blood disorders like agranulocytosis, and anaphylactic reactions. Patients should seek immediate medical attention if they notice signs of liver dysfunction, rash, or unexplained bleeding.

Individuals with known hypersensitivity to chlorzoxazone or any of its excipients should avoid the product. Caution is also advised for patients with severe hepatic impairment, those taking multiple CNS depressants, and pregnant or nursing women unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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