Product image of Klotrimasool Gsk (Clotrimazole) supplied by GNH India

Klotrimasool Gsk

Active Ingredient:
Clotrimazole
Origin:
EU

Klotrimasool Gsk (Clotrimazole)

Clotrimazole, the active ingredient in Klotrimasool Gsk, is a azole antifungal presented as a topical formulation for skin application. It treats fungal infections such as athlete's foot, ringworm, candidiasis and intertrigo in adults and children.
GNH India supplies Klotrimasool Gsk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Trading Services Limited

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Indications & Clinical Uses

Clotrimazole acts on dermatophyte and yeast infections of the skin and superficial mucous membranes.

  • Tinea pedis: reduces fungal growth and relieves itching, scaling and redness.
  • Tinea corporis: clears ring-shaped lesions and prevents spread of infection.
  • Candidiasis: eliminates yeast overgrowth on skin folds and restores normal skin integrity.
  • Intertrigo: controls fungal colonisation in moist intertriginous areas and reduces irritation.

How It Works

  • Clotrimazole inhibits ergosterol synthesis by blocking the fungal enzyme lanosterol 14α-demethylase. This disruption compromises the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby halting the progression of superficial fungal infections.

Side Effects

Clotrimazole is generally well tolerated when applied topically, but local reactions can occur.

Common Side Effects

  • Burning sensation at the application site
  • Itching or mild irritation
  • Redness or erythema
  • Stinging feeling
  • Dryness of the skin
  • Mild peeling

Serious or Rare Side Effects

  • Allergic contact dermatitis
  • Severe skin irritation or swelling
  • Blister formation
  • Extensive rash
  • Anaphylactic reaction (rare)
  • Persistent ulceration of the skin

Precautions & Warnings

Before using Klotrimasool Gsk, consider the following safety measures.

  • Avoid use on broken or inflamed skin: may increase irritation.
  • Do not apply to eyes, ears, or mucous membranes: risk of severe irritation.
  • Discontinue if a rash or worsening redness develops: seek medical advice.
  • Consult a healthcare professional before use in children under 2 years: safety not established.
  • Avoid concurrent use with other topical irritants unless directed: may enhance adverse reactions.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Clotrimazole has limited systemic interactions, but topical use may affect other skin products.

Major Interactions (Avoid)

  • Concurrent use with other topical irritants: may increase skin irritation.
  • Use with systemic azole antifungals: potential for increased systemic absorption (rare).

Moderate Interactions (Monitor Closely)

  • Use with corticosteroid creams: may mask signs of infection.
  • Use with other antifungal agents: may cause additive irritation.
  • Application together with sunscreen or cosmetic products: may affect drug absorption.

Frequently Asked Questions

Klotrimasool Gsk contains clotrimazole and is indicated for the topical treatment of superficial fungal infections such as athlete's foot (tinea pedis), body ringworm (tinea corporis), cutaneous candidiasis and intertrigo. It helps to eliminate the fungi causing these conditions and relieves associated symptoms like itching and redness.

Clotrimazole interferes with the synthesis of ergosterol, an essential component of fungal cell membranes, by inhibiting the enzyme lanosterol 14α-demethylase. This disruption weakens the membrane, leading to increased permeability, loss of cellular contents, and ultimately fungal cell death.

The dosage and frequency of application are determined by the prescribing healthcare professional based on the type and severity of the infection. Patients should follow the specific instructions provided on the product label or by their clinician.

Safety data for topical clotrimazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits with their healthcare provider before using this product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clotrimazole is a broad‑spectrum azole antifungal that is effective against many dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole generally has a similar efficacy for mild to moderate skin infections but may be preferred for its established safety profile and OTC availability.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, direct sunlight and excessive heat to maintain its stability and effectiveness.

Apply a thin layer of the cream or ointment to the affected skin area, usually twice daily, after washing and drying the skin. Gently rub it in until fully absorbed, and wash hands after application unless the hands are being treated.

While rare, serious adverse reactions can include severe allergic contact dermatitis, extensive skin swelling, blistering, or anaphylaxis. If any of these symptoms develop, discontinue use immediately and seek medical attention.

Individuals with a known hypersensitivity to clotrimazole or any component of the formulation should avoid using this product. It should also not be applied to broken skin, eyes, ears, or mucous membranes, and use in very young children should be guided by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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