Product image of Klotrimazol Pliva (Clotrimazole) supplied by GNH India

Klotrimazol Pliva

Active Ingredient:
Clotrimazole
Origin:
EU

Klotrimazol Pliva (Clotrimazole)

Clotrimazole, the active ingredient in Klotrimazol Pliva, is an imidazole antifungal presented as a vaginal formulation for intravaginal use. It treats vaginal candidiasis and other yeast infections of the vagina in adult women.

GNH India supplies Klotrimazol Pliva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent manufacturing standards and provides reliable logistics for consistent product availability across global markets.

Manufacturer / TM Owner

Pliva Hrvatska D.O.O.

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Indications & Clinical Uses

Clotrimazole acts on fungal cell membranes to treat infections within the vaginal tract.

  • Vaginal candidiasis: treatment of acute yeast infection of the vagina.
  • Recurrent vulvovaginal candidiasis: helps reduce the frequency of recurring episodes.
  • Yeast infection of the vagina: alleviates symptoms such as itching, burning and abnormal discharge.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this enzyme, the drug disrupts the formation of ergosterol, an essential component of fungal cell membranes, leading to increased membrane permeability and ultimately fungal cell death.

Side Effects

Clotrimazole may cause local adverse reactions when applied intravaginally.

Common Side Effects

  • Irritation or burning at the application site.
  • Itching or mild discomfort.
  • Vaginal discharge that may be watery or whitish.
  • Dryness of the vaginal mucosa.
  • Unpleasant odor.

Serious or Rare Side Effects

  • Allergic reaction such as rash, hives, or swelling.
  • Severe skin reactions including Stevens‑Johnson syndrome.
  • Swelling of the face, lips or tongue.
  • Difficulty breathing or throat tightness.
  • Rare liver toxicity manifested by jaundice or abnormal liver tests.

Precautions & Warnings

Before using Klotrimazol Pliva, consider the following precautions.

  • Assess for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Avoid use if there is a known non‑Candida vaginal infection.
  • Do not apply during active menstrual bleeding if irritation is present.
  • Consult a healthcare professional before use during pregnancy or breastfeeding.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clotrimazol may interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Concurrent systemic azole antifungals may increase systemic exposure and toxicity.
  • Use with other irritating vaginal products may exacerbate local irritation.

Moderate Interactions (Monitor Closely)

  • Co‑administration with spermicides may reduce antifungal efficacy.
  • Use with hormonal contraceptives generally shows no significant interaction but monitoring is advised.
  • Simultaneous use of multiple vaginal medications may affect absorption and effectiveness.

Frequently Asked Questions

Klotrimazol Pliva is a vaginal formulation containing clotrimazole, an imidazole antifungal. It is used to treat vaginal candidiasis and other yeast infections of the vagina, helping to relieve symptoms such as itching, burning, and abnormal discharge.

Clotrimazole works by inhibiting the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. Disruption of ergosterol production weakens the fungal cell membrane, leading to increased permeability and ultimately fungal cell death.

The specific dosing regimen for Klotrimazol Pliva is determined by the prescribing healthcare professional based on the severity of the infection and patient factors. Patients should follow the instructions provided by their prescriber and the product label.

Safety of clotrimazole during pregnancy or breastfeeding has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider before using the product.

To order Klotrimazol Pliva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Klotrimazol Pliva contains clotrimazole, a widely used imidazole antifungal with a well‑established efficacy profile. Compared with other vaginal antifungals such as miconazole or tioconazole, clotrimazole offers similar cure rates for uncomplicated vaginal candidiasis, with a favorable safety and tolerability record.

Store Klotrimazol Pliva at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Klotrimazol Pliva is applied intravaginally. The prescribed amount is inserted into the vagina using the supplied applicator or as directed by the healthcare professional, typically once daily for the duration recommended by the prescriber.

Serious risks, though rare, include severe allergic reactions such as rash, swelling of the face or lips, difficulty breathing, and rare severe skin reactions like Stevens‑Johnson syndrome. If any of these occur, discontinue use immediately and seek medical attention.

Klotrimazol Pliva should not be used by individuals with a known hypersensitivity to clotrimazole or any other component of the formulation, or by those with a non‑Candida vaginal infection without medical advice. Pregnant or breastfeeding women should consult a healthcare provider before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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