Product image of Klotrimazolas Polpharm (Clotrimazole) supplied by GNH India

Klotrimazolas Polpharm

Active Ingredient:
Clotrimazole
Origin:
EU

Klotrimazolas Polpharm (Clotrimazole)

Clotrimazole, the active ingredient in Klotrimazolas Polpharm, is an imidazole antifungal presented as a topical formulation for cutaneous use. It treats superficial fungal infections such as athlete’s foot, ringworm and cutaneous yeast infections in adults and children.

GNH India supplies Klotrimazolas Polpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Clotrimazole is used to treat fungal skin infections by targeting the dermatophyte and yeast pathogens that cause these conditions.
  • Tinea corporis: clears ring‑shaped lesions on the body.
  • Tinea pedis: relieves itching and scaling of athlete’s foot.
  • Candidiasis: eliminates cutaneous yeast infections.
  • Dermatophytosis: eradicates skin fungal spread.

How It Works

  • Clotrimazole exerts its antifungal effect by inhibiting the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. This disruption compromises the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death. Because ergosterol is essential for fungal membrane fluidity, its depletion hampers growth and replication of susceptible organisms.

Side Effects

Clotrimazole may cause local skin reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation: redness or itching at the application site.
  • Burning sensation: mild transient burning after application.
  • Itching: localized pruritus.
  • Dryness: localized skin dryness.

Serious or Rare Side Effects

  • Contact dermatitis: allergic reaction with swelling and rash.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Angioedema: swelling of deeper skin layers.

Precautions & Warnings

When using Klotrimazolas Polpharm, follow these safety measures.

  • Application area: apply a thin layer to clean, dry skin.
  • Duration: limit use to the period recommended by a healthcare professional.
  • Avoid eyes: keep the product away from eyes and mucous membranes.
  • Use in children: consult a healthcare professional before use in pediatric patients.
  • Pregnancy and lactation: discuss with a physician before use.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Clotrimazole may interact with other topical or systemic agents; consider the following.

Major Interactions (Avoid)

  • Concurrent use with other topical azole antifungals may increase local irritation.
  • Use with systemic antifungal agents metabolized by CYP450 may alter plasma levels, although topical absorption is minimal.
  • Co‑application with corticosteroids may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Use with occlusive dressings may enhance absorption.
  • Combination with other skin irritants (e.g., retinoids) may increase local reactions.
  • Use with alcohol‑based cleansers may affect drug stability.

Frequently Asked Questions

Klotrimazolas Polpharm contains clotrimazole, a topical antifungal indicated for the treatment of superficial fungal skin infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis), cutaneous candidiasis and other dermatophytoses. It is applied directly to the affected area to relieve symptoms and eradicate the infecting organisms.

Clotrimazole works by inhibiting the fungal enzyme lanosterol 14α‑demethylase, which is essential for the synthesis of ergosterol, a key component of fungal cell membranes. Disruption of ergosterol production weakens the membrane, leading to increased permeability, impaired growth, and ultimately fungal cell death.

The specific dosing regimen for Klotrimazolas Polpharm is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and the product’s concentration. Typically, a thin layer is applied to the affected skin once or twice daily for the duration recommended by the prescriber.

Safety data for clotrimazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Klotrimazolas Polpharm with their physician. The prescriber will weigh potential benefits against any possible risks to the mother and infant.

To request Klotrimazolas Polpharm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any required import documentation.

Clotrimazole is an imidazole antifungal with a broad spectrum against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole generally has a similar efficacy for mild to moderate infections but may be less potent for certain resistant strains. Its safety profile is well‑established, and it is available over‑the‑counter in many markets.

Store Klotrimazolas Polpharm at room temperature, typically below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, heat and direct sunlight. Do not freeze the product. Ensure the container is kept out of reach of children.

Klotrimazolas Polpharm is applied topically. Clean and dry the affected skin area, then spread a thin layer of the cream or ointment over the lesion. Wash hands after application unless the hands are the treatment site. Follow the prescriber’s instructions regarding frequency and duration of use.

While most reactions are mild, serious adverse events can occur. These include allergic contact dermatitis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and angioedema. If any signs of severe skin reaction, swelling, blistering, or systemic symptoms develop, discontinue use immediately and seek medical attention.

Individuals with a known hypersensitivity to clotrimazole or any component of the formulation should avoid using Klotrimazolas Polpharm. It is also contraindicated on large areas of broken skin, in patients with extensive mucosal involvement, and in infants unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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