Product image of Klysmol (Sodium Phosphate Dibasic Heptahydrate, Sodium Dihydrogen Phosphate Monohydrate) supplied by GNH India

Klysmol

Active Ingredient:
Sodium Phosphate Dibasic Heptahydrate, Sodium Dihydrogen Phosphate Monohydrate
Origin:
EU

Klysmol (Sodium Phosphate Dibasic Heptahydrate, Sodium Dihydrogen Phosphate Monohydrate)

Sodium Phosphate Dibasic Heptahydrate / Sodium Dihydrogen Phosphate Monohydrate, the active ingredient in Klysmol, is an osmotic laxative presented as a rectal solution for rectal use. It is employed to cleanse the bowel before diagnostic procedures and to relieve constipation in adult patients.

GNH India supplies Klysmol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

The Star Medicines Importers Co Ltd

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Indications & Clinical Uses

  • Klysmol is an osmotic laxative that works within the gastrointestinal tract to promote bowel evacuation.
  • Bowel preparation: facilitates colon cleansing before colonoscopy or radiologic imaging.
  • Constipation: stimulates bowel movements to relieve functional constipation in adults.

How It Works

  • Sodium phosphate dibasic heptahydrate and sodium dihydrogen phosphate monohydrate create an osmotic gradient in the colon. The resulting increase in intraluminal osmolarity draws water from the surrounding tissues into the intestinal lumen, softening stool and stimulating peristalsis, which leads to bowel evacuation.

Side Effects

Klysmol may cause several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Abdominal cramping or discomfort.
  • Nausea or mild vomiting.
  • Rectal irritation or burning sensation.
  • Transient electrolyte disturbances (e.g., mild hyperphosphatemia).
  • Thirst or mild dehydration.
  • Flatulence or bloating.

Serious or Rare Side Effects

  • Severe electrolyte imbalance such as hyperphosphatemia, hypocalcemia, or hyperkalemia.
  • Acute renal dysfunction or failure.
  • Marked dehydration leading to hypotension.
  • Colonic perforation (very rare).
  • Severe abdominal pain indicating possible obstruction.

Precautions & Warnings

  • Before using Klysmol, consider the following safety measures.
  • Assess renal function: avoid in patients with severe renal impairment.
  • Monitor electrolytes: check serum phosphate, calcium, and potassium levels.
  • Use with caution in dehydration: ensure adequate hydration before administration.
  • Avoid in bowel obstruction: contraindicated in mechanical obstruction.
  • Medical supervision required: administration should be overseen by qualified healthcare personnel.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Klysmol can interact with other medicines that affect fluid or electrolyte balance.

Major Interactions (Avoid)

  • Calcium carbonate or calcium supplements: may exacerbate hyperphosphatemia.
  • Aluminum‑containing antacids: can reduce phosphate absorption and alter efficacy.
  • Loop diuretics: increase risk of severe electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor renal function and electrolytes.
  • NSAIDs: may increase risk of renal impairment.
  • Digoxin: electrolyte shifts can affect cardiac glycoside toxicity.

Frequently Asked Questions

Klysmol is used as an osmotic laxative for bowel cleansing prior to diagnostic procedures such as colonoscopy, and for the relief of constipation in adult patients. It works by drawing water into the colon to promote evacuation.

The active ingredients, sodium phosphate dibasic heptahydrate and sodium dihydrogen phosphate monohydrate, create an osmotic gradient in the colon. This gradient pulls water from surrounding tissues into the intestinal lumen, softening stool and stimulating peristalsis, which results in bowel movement.

The dose of Klysmol is determined by the prescribing healthcare professional based on the specific clinical situation, patient characteristics, and intended use. Patients should follow the prescriber’s instructions and not self‑adjust the amount.

Safety data for Klysmol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Klysmol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Klysmol is an osmotic laxative that uses phosphate salts to draw water into the colon, whereas other agents such as polyethylene glycol solutions rely on large volumes of fluid. Klysmol typically requires a smaller volume but may have a higher risk of electrolyte disturbances, so patient selection and monitoring differ.

Klysmol should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain stability and potency.

Klysmol is supplied as a rectal solution and is administered via rectal insertion. The exact method, volume, and timing are determined by the prescribing clinician and should be performed under medical supervision.

Serious risks include severe electrolyte imbalances such as hyperphosphatemia, hypocalcemia, or hyperkalemia, acute renal dysfunction, marked dehydration, and, rarely, colonic perforation. Patients should be monitored closely for these complications, especially if they have pre‑existing kidney disease or are taking interacting medications.

Klysmol should not be used in patients with severe renal impairment, known bowel obstruction, or hypersensitivity to phosphate preparations. It is also contraindicated in individuals with uncontrolled electrolyte disorders or those at high risk for dehydration without appropriate medical oversight.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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